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Heart. 2000 September; 84(3): e7.
PMCID: PMC1760952

Coexistence of giant aneurysm of sinus of Valsalva and coronary artery aneurysm associated with idiopathic hypereosinophilic syndrome


Aneurysms of the coronary sinuses of Valsalva and coronary artery aneurysms are uncommon cardiac anomalies, and cases in which these two uncommon lesions occur at the same time are extremely rare. A case of a woman with unstable angina who had a giant aneurysm of the left coronary sinus and multiple coronary artery aneurysms associated with an idiopathic hypereosinophilic syndrome is presented. Her sustained eosinophilia, elevated eosinophilic cationic protein concentration, and pathological findings of eosinophil infiltration of the aortic wall suggested the association of eosinophilia induced vascular injury as the cause of these aneurysms. This is the first such case to survive following surgical treatment.

Keywords: aneurysm; arteritis; coronary sinus; eosinophilia

Figure 1
(A) Root aortogram showing a giant left sinus of Valsalva aneurysm (arrows), and enlarged right and non-coronary sinuses in left anterior oblique (LAO) projection. (B) A selective injection into the left coronary sinus aneurysm defining a large aneurysm ...
Figure 2
Histological section of the aorta with pronounced infiltration of eosinophils and mononuclear cells in its media (haematoxylin and eosin stain × 100).

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