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Ann Rheum Dis. 2004 September; 63(9): 1162–1165.
PMCID: PMC1755128

Increased matrix concentrations of IGFBP-5 in cancellous bone in osteoarthritis

Abstract

Objectives: To measure IGF-I, IGF-II, and IGFBP-5 in femoral head bone from non-OA controls and patients with OA, and to relate these to apparent density (ρA) and elastic modulus (Ec).

Methods: ρA, Ec, and IGF system components were measured in cancellous bone from superior and inferior regions of femoral heads from 31 patients with OA and 11 age selected controls.

Results: Ec and ρA were greater (p<0.05) in the superior region of all femoral heads. In primary OA, ρA was increased in the inferior region (p<0.05). IGFBP-5 was increased, about twofold, at superior and inferior regions in primary OA (1.60 and 1.54 ng/mg bone, respectively, both p<0.05) and in Paget's disease (2.44 and 1.75 ng/mg bone, both p<0.05) compared with controls (0.73 and 0.95 ng/mg bone). In controls, inverse correlations between IGFBP-5 and both ρA and Ec at superior (rs = –0.64 and –0.73, both p<0.05) and inferior regions (rs = –0.72, p<0.05 and –0.24 (NS)) were seen, but these were lost in OA.

Conclusions: IGFBP-5 may modulate cancellous bone formation by negative feedback. In end stage OA this is disrupted, but has little influence on material properties.

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Figures and Tables

Figure 1
 Relationships between ρA of the bone cores and IGFBP-5 extracted from the bone matrix. Triangles = healthy controls, circles = primary OA, diamonds = secondary OA (Paget's disease). Open symbols represent inferior and closed symbols ...
Figure 2
 Relationships between the compressive modulus of the bone cores and IGFBP-5 extracted from the bone matrix. Triangles = healthy controls, circles = primary OA, diamonds = secondary OA (Paget's disease). Open symbols represent inferior and closed ...

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