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Thorax. Mar 2005; 60(3): 226–228.
PMCID: PMC1747321
Structural changes to airway smooth muscle in cystic fibrosis
S Hays, R Ferrando, R Carter, H Wong, and P Woodruff
Moffitt Hospital, 505 Parnassus Ave, San Francisco, CA 94143, USA.
Background: Chronic airway obstruction is characteristic of cystic fibrosis (CF) but there are few studies of airway smooth muscle remodelling in CF.
Methods: Airway smooth muscle content and mean airway smooth muscle cell size were measured by applying design-based stereology to bronchoscopic biopsy specimens obtained from seven subjects with CF and 15 healthy controls.
Results: The smooth muscle content increased by 63% in subjects with CF (mean (SD) 0.173 (0.08) v 0.106 (0.042) mm3 smooth muscle/mm3 submucosa, mean difference –0.067; 95% CI –0.12 to –0.013, p = 0.017) but there was no increase in mean cell size (2705 (351) v 2654 (757) µm3, mean difference –51; 95% CI –687 to 585, p = 0.87).
Conclusions: These findings indicate hyperplasia of airway smooth muscle cells without hypertrophy and suggest that accumulation of airway smooth muscle cells may contribute to airway narrowing and bronchial hyperresponsiveness in CF.
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