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Infect Immun. Dec 1996; 64(12): 5421–5424.
PMCID: PMC174542
Recognition of immunoglobulin A1 by oral actinomyces and streptococcal lectins.
S Ruhl, A L Sandberg, M F Cole, and J O Cisar
Laboratory of Microbial Ecology, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892, USA.
Actinomyces naeslundii and Streptococcus gordonii, oral bacteria that possess Gal/GalNAc- and sialic acid-reactive lectins, respectively, were adherent to immobilized secretory immunoglobulin A (IgA) and two IgA1 myeloma proteins but not to two IgA2 myeloma proteins. Apparently, O-linked oligosaccharides at the hinge region of the IgA1 heavy chain are receptors for lectin-mediated adhesion of these bacteria.
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