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Infect Immun. Nov 1996; 64(11): 4830–4833.
PMCID: PMC174452
Role of neutrophils in controlling early stages of a Chlamydia trachomatis infection.
N Barteneva, I Theodor, E M Peterson, and L M de la Maza
Department of Pathology, University of California, Irvine 92697-4800, USA.
Inoculation of mice with the granulocyte-depleting monoclonal antibody RB6-8C5 showed that neutrophils are critical protective effector cells during a Chlamydia trachomatis infection. In addition, administration of monoclonal antibody 2E6 demonstrated that extravasation of neutrophils into the peritoneal cavity in response to inoculation with the C. trachomatis MoPn biovar is dependent on the surface beta-2 integrin molecule CD18.
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