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Postgrad Med J. 2000 April; 76(894): 254–256.
PMCID: PMC1741568

Venlafaxine-induced serotonin syndrome with relapse following amitriptyline


A case of venlafaxine-induced serotonin syndrome is described with relapse following the introduction of amitriptyline, despite a 2-week period between the discontinuation of one drug and the commencement of the other. Electroencephalography may play an important part in diagnosis. With the increasing use of selective serotonin re-uptake inhibitors, greater awareness of the serotonin syndrome is necessary. Furthermore, the potential for drug interactions which may lead to the syndrome needs to be recognised.

Keywords: serotonin syndrome; venlafaxine; amitriptyline; adverse drug reaction

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