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Logo of jnnpsycJournal of Neurology, Neurosurgery and PsychiatryVisit this articleSubmit a manuscriptReceive email alertsContact usBMJ
J Neurol Neurosurg Psychiatry. 2005 October; 76(10): 1440–1444.
PMCID: PMC1739360

APOE related alterations in cerebral activation even at college age


Objective: To explore APOE related alterations during cognitive activation in a population of young adults.

Methods: Using H215O positron emission tomography (PET), imaging was carried out in 20 healthy young adults (age 19 to 28 years; four ε4 carriers and 16 non-ε4 carriers) during a non-verbal memory task. Voxel-wise multiple regression analyses were undertaken, with the activation difference PET counts as the dependent variable and the APOE genotype as the independent variable.

Results: Brain regions were identified where ε4 carriers showed significantly lower or higher activation than non-carriers.

Conclusions: The results suggest that APOE dependent modulation of cerebral flow may be present even at a young age. This may reflect an APOE related physiological heterogeneity which may or may not predispose to brain disease in the ensuing decades or, less likely, the effect of very early Alzheimer's disease related pathological changes.

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