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This study investigated possible associations between
selected polymorphisms in the dopamine receptor genes DRD1 and DRD3 with the presence of psychotic phenomena or aggressive behaviour in a
community based cohort of 134 patients with late onset Alzheimer's disease. An association was found between the presence of psychotic symptoms and aggressive behaviour and the DRD1 polymorphism and between
the presence of psychosis, but not aggression, and the DRD3
polymorphism. Specifically, carriers of the DRD1 B2 allele were more
likely to be aggressive or experience hallucinations whereas homozygous
carriers of the DRD3 1 allele were more likely to experience delusions.