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J Clin Pathol. 2001 August; 54(8): 640–641.
PMCID: PMC1731497

Eosinophilic angiocentric fibrosis and Wegener's granulomatosis: a case report and literature review

Abstract

This report presents a case of eosinophilic angiocentric fibrosis in a man with Wegener's granulomatosis, the first report of a possible association between the two conditions. This association suggests a possible mechanism for its pathogenesis.

Key Words: Wegener's granulomatosis • eosinophilic angiocentric fibrosis • nose

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Figure 1 Established lesion of eosinophilic angiocentric fibrosis: perivascular fibrosis with obliteration of vessel lumens. Adjacent inflammatory infiltrate comprises eosinophils, lymphocytes, and plasma cells (haematoxylin and eosin).
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Figure 2 The initial nasal biopsy demonstrating giant cells, numerous plasma cells, neutrophils, and occasional eosinophils (haematoxylin and eosin).

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