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J Clin Pathol. Dec 2001; 54(12): 961–963.
PMCID: PMC1731338
Prominent dyserythropoiesis in four cases of haemophagocytic lymphohistiocytosis
M Macheta, A Will, J Houghton, and R Wynn
Department of Paediatric Haematology, Royal Manchester Children's Hospital, Hospital Road, Pendlebury, Manchester M27 4HA, UK.
Haemophagocytic lymphohistiocytosis (HLH) is a disease characterised by peripheral blood pancytopenia secondary to haemophagocytosis of formed blood cells by activated histiocytes. The demonstration of haemophagocytosis may be difficult and the diagnosis may require repeated tissue sampling (including bone marrow, cerebrospinal fluid, lymph nodes, spleen, and liver) and the demonstration of associated clinical or laboratory features. This report describes pronounced dyserythropoiesis in the bone marrow aspirates in four patients with HLH, including familial and secondary cases. In three patients, bone marrow haemophagocytosis was inconspicuous or absent, and the prominent dyserythropoiesis may have suggested an alternative diagnosis. The dyserythropoiesis observed should be added to the constellation of clinical and laboratory features associated with HLH.
Key Words: haemophagocytic lymphohistiocytosis • dyserythropoiesis • familial haemophagocytic lymphohistiocytosis
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Figure 1 Photomicrograph of the bone marrow aspirate in case 1 showing erythroblasts with trilobed and "clover leaf" nuclei, chromatin fragmentation, and early megaloblastic changes (Wright's stain).
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Figure 2 Photomicrograph of the bone marrow aspirate in case 3 showing abnormal erythroblasts with three nuclei or bilobed nuclei (Wright's stain).
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