Search tips
Search criteria 


Logo of iaiPermissionsJournals.ASM.orgJournalIAI ArticleJournal InfoAuthorsReviewers
Infect Immun. Feb 1995; 63(2): 672–675.
PMCID: PMC173047
Relationship of secretion pattern and MPB70 homology with osteoblast-specific factor 2 to osteitis following Mycobacterium bovis BCG vaccination.
J C Ulstrup, S Jeansson, H G Wiker, and M Harboe
Department of Microbiology, Ullevål University Hospital, Oslo, Norway.
Significant homology was found between MPB70 and each of four repeat domains of osteoblast-specific factor 2 (OSF-2). Two internal homology regions within each repeat domain of OSF-2 presumed to be related to the active site(s) of this bone adhesion molecule showed the highest homology. A literature search concerning osteitis after Mycobacterium bovis BCG vaccination in neonates revealed that MPB70-high-producer substrains were associated with an increased incidence of osteitis following vaccination. These observations indicate that the function of MPB70 is related to the interaction between bacilli and the host following vaccination or infection with mycobacteria.
Full Text
The Full Text of this article is available as a PDF (179K).
Articles from Infection and Immunity are provided here courtesy of
American Society for Microbiology (ASM)