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Gut. 1998 May; 42(5): 750–752.
PMCID: PMC1727106

Tranexamic acid for severe bleeding gastric antral vascular ectasia in cirrhosis

Abstract

Background—It is believed that severe portal hypertensive gastropathy probably accounts for most non-variceal bleeding episodes in patients with cirrhosis. Gastric antral vascular ectasia (GAVE) also occurs in these patients. It is not clear whether it is a variant of portal hypertensive gastropathy or a distinct condition.
Patient—A patient, a 66 year od woman, with cirrhosis initially diagnosed as having portal hypertensive gastropathy and subsequently classified as GAVE is described. She required transfusion with a total of 130 units of packed red cells for gastrointestinal blood loss.
Results—The bleeding did not respond to portal decompression with TIPS or beta blockers. Following treatment with oral tranexamic acid she has not required further blood transfusion over a period of 30months.
Conclusion—Tranexamic acid may be a useful treatment for refractory bleeding due to gastric antral vascular ectasia in patients with cirrhosis.

Keywords: gastric antral vascular ectasia; cirrhosis; tranexamic acid

Figure 1
Monthly blood transfusion requirements and treatment received for blood loss from gastric antral vascular ectasia. At the time of writing the patient has not required blood transfusion for 19 months. TIPS, transjugular intrahepatic portosystemic shunt. ...

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