Search tips
Search criteria 


Logo of brjopthalBritish Journal of OphthalmologyCurrent TOCInstructions for authors
Br J Ophthalmol. Sep 2001; 85(9): 1044–1045.
PMCID: PMC1724129
Is the partial pressure of carbon dioxide in the blood related to the development of retinopathy of prematurity?
B. Gellen, N. McIntosh, J. McColm, and B. Fleck
Child Life and Health, Reproductive and Developmental Sciences, Edinburgh University, UK.
AIMS—To determine the role of carbon dioxide in the development of retinopathy of prematurity (ROP).
METHODS—This was a retrospective cohort study of 25 consecutive infants admitted to the neonatal unit with continuously recorded physiological data. The daily mean and standard deviation (SD) of transcutaneous carbon dioxide partial pressure (tcPCO2) was compared between infants who had stage 1 or 2 ROP and stage 3 ROP. The time spent hypocarbic (<3 kPa) and/or hypercarbic (>10 kPa and >12 kPa) was also compared between these groups. Intermittent arterial carbon dioxide tension was also measured and compared with the simultaneous tcPCO2 data.
RESULTS—There were no significant differences in carbon dioxide variability or time spent hypocarbic and/or hypercarbic between the ROP groups on any day. 86% of transcutaneous values were within 1.5 kPa of the simultaneous arterial value.
CONCLUSION—TcPCO2 measurement can be a very useful management technique. However, in this cohort neither variable blood carbon dioxide tension nor duration of hypercarbia or hypocarbia in the first 2 weeks of life was associated with the development or severity of ROP.

Figure 1
Figure 1  
The comparison of transcutaneous and simultaneous arterial PCO2. These data are displayed as a Bland-Altman plot; 85.8% of transcutaneous values being within 1.5 kPa of the simultaneous arterial value (1.5 kPa or less difference between (more ...)
Articles from The British Journal of Ophthalmology are provided here courtesy of
BMJ Group