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Br J Ophthalmol. 1998 August; 82(8): 907–910.
PMCID: PMC1722697

Fruits and vegetables that are sources for lutein and zeaxanthin: the macular pigment in human eyes

Abstract

BACKGROUND—It has been suggested that eating green leafy vegetables, which are rich in lutein and zeaxanthin, may decrease the risk for age related macular degeneration. The goal of this study was to analyse various fruits and vegetables to establish which ones contain lutein and/or zeaxanthin and can serve as possible dietary supplements for these carotenoids.
METHODS—Homogenates of 33 fruits and vegetables, two fruit juices, and egg yolk were used for extraction of the carotenoids with hexane. Measurement of the different carotenoids and their isomers was carried out by high performance liquid chromatography using a single column with an isocratic run, and a diode array detector.
RESULTS—Egg yolk and maize (corn) contained the highest mole percentage (% of total) of lutein and zeaxanthin (more than 85% of the total carotenoids). Maize was the vegetable with the highest quantity of lutein (60% of total) and orange pepper was the vegetable with the highest amount of zeaxanthin (37% of total). Substantial amounts of lutein and zeaxanthin (30-50%) were also present in kiwi fruit, grapes, spinach, orange juice, zucchini (or vegetable marrow), and different kinds of squash. The results show that there are fruits and vegetables of various colours with a relatively high content of lutein and zeaxanthin.
CONCLUSIONS—Most of the dark green leafy vegetables, previously recommended for a higher intake of lutein and zeaxanthin, have 15-47% of lutein, but a very low content (0-3%) of zeaxanthin. Our study shows that fruits and vegetables of various colours can be consumed to increase dietary intake of lutein and zeaxanthin.

Keywords: age related macular degeneration; carotenoids; dietary intake; macular pigment

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Selected References

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  • Handelman GJ, Dratz EA, Reay CC, van Kuijk JG. Carotenoids in the human macula and whole retina. Invest Ophthalmol Vis Sci. 1988 Jun;29(6):850–855. [PubMed]
  • Bone RA, Landrum JT, Fernandez L, Tarsis SL. Analysis of the macular pigment by HPLC: retinal distribution and age study. Invest Ophthalmol Vis Sci. 1988 Jun;29(6):843–849. [PubMed]
  • Snodderly DM, Handelman GJ, Adler AJ. Distribution of individual macular pigment carotenoids in central retina of macaque and squirrel monkeys. Invest Ophthalmol Vis Sci. 1991 Feb;32(2):268–279. [PubMed]
  • Gerster H. Review: antioxidant protection of the ageing macula. Age Ageing. 1991 Jan;20(1):60–69. [PubMed]
  • Schalch W, Weber P. Vitamins and carotenoids--a promising approach to reducing the risk of coronary heart disease, cancer and eye diseases. Adv Exp Med Biol. 1994;366:335–350. [PubMed]
  • Young RW. Solar radiation and age-related macular degeneration. Surv Ophthalmol. 1988 Jan-Feb;32(4):252–269. [PubMed]
  • Hammond BR, Jr, Fuld K, Snodderly DM. Iris color and macular pigment optical density. Exp Eye Res. 1996 Mar;62(3):293–297. [PubMed]
  • Hammond BR, Jr, Johnson EJ, Russell RM, Krinsky NI, Yeum KJ, Edwards RB, Snodderly DM. Dietary modification of human macular pigment density. Invest Ophthalmol Vis Sci. 1997 Aug;38(9):1795–1801. [PubMed]
  • Jacques PF, Chylack LT., Jr Epidemiologic evidence of a role for the antioxidant vitamins and carotenoids in cataract prevention. Am J Clin Nutr. 1991 Jan;53(1 Suppl):352S–355S. [PubMed]
  • Seddon JM, Ajani UA, Sperduto RD, Hiller R, Blair N, Burton TC, Farber MD, Gragoudas ES, Haller J, Miller DT, et al. Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration. Eye Disease Case-Control Study Group. JAMA. 1994 Nov 9;272(18):1413–1420. [PubMed]
  • West S, Vitale S, Hallfrisch J, Muñoz B, Muller D, Bressler S, Bressler NM. Are antioxidants or supplements protective for age-related macular degeneration? Arch Ophthalmol. 1994 Feb;112(2):222–227. [PubMed]
  • Mares-Perlman JA, Brady WE, Klein R, Klein BE, Bowen P, Stacewicz-Sapuntzakis M, Palta M. Serum antioxidants and age-related macular degeneration in a population-based case-control study. Arch Ophthalmol. 1995 Dec;113(12):1518–1523. [PubMed]
  • Snodderly DM. Evidence for protection against age-related macular degeneration by carotenoids and antioxidant vitamins. Am J Clin Nutr. 1995 Dec;62(6 Suppl):1448S–1461S. [PubMed]
  • Landrum JT, Bone RA, Kilburn MD. The macular pigment: a possible role in protection from age-related macular degeneration. Adv Pharmacol. 1997;38:537–556. [PubMed]
  • Mangels AR, Holden JM, Beecher GR, Forman MR, Lanza E. Carotenoid content of fruits and vegetables: an evaluation of analytic data. J Am Diet Assoc. 1993 Mar;93(3):284–296. [PubMed]
  • Sommerburg O, Zang LY, van Kuijk FJ. Simultaneous detection of carotenoids and vitamin E in human plasma. J Chromatogr B Biomed Sci Appl. 1997 Aug 1;695(2):209–215. [PubMed]
  • Krinsky NI. Actions of carotenoids in biological systems. Annu Rev Nutr. 1993;13:561–587. [PubMed]
  • Forman MR, Lanza E, Yong LC, Holden JM, Graubard BI, Beecher GR, Meltiz M, Brown ED, Smith JC. The correlation between two dietary assessments of carotenoid intake and plasma carotenoid concentrations: application of a carotenoid food-composition database. Am J Clin Nutr. 1993 Oct;58(4):519–524. [PubMed]
  • Micozzi MS. Evaluation of carotenoid intake. Methods Enzymol. 1993;214:17–21. [PubMed]
  • Scita G, Aponte GW, Wolf G. Uptake and cleavage of beta-carotene by cultures of rat small intestinal cells and human lung fibroblasts. Methods Enzymol. 1993;214:21–32. [PubMed]
  • Clevidence BA, Bieri JG. Association of carotenoids with human plasma lipoproteins. Methods Enzymol. 1993;214:33–46. [PubMed]
  • Yeum KJ, Taylor A, Tang G, Russell RM. Measurement of carotenoids, retinoids, and tocopherols in human lenses. Invest Ophthalmol Vis Sci. 1995 Dec;36(13):2756–2761. [PubMed]
  • Malinow MR, Feeney-Burns L, Peterson LH, Klein ML, Neuringer M. Diet-related macular anomalies in monkeys. Invest Ophthalmol Vis Sci. 1980 Aug;19(8):857–863. [PubMed]
  • Hammond BR, Jr, Fuld K, Curran-Celentano J. Macular pigment density in monozygotic twins. Invest Ophthalmol Vis Sci. 1995 Nov;36(12):2531–2541. [PubMed]
  • Schnohr P, Thomsen OO, Riis Hansen P, Boberg-Ans G, Lawaetz H, Weeke T. Egg consumption and high-density-lipoprotein cholesterol. J Intern Med. 1994 Mar;235(3):249–251. [PubMed]
  • Ginsberg HN, Karmally W, Siddiqui M, Holleran S, Tall AR, Rumsey SC, Deckelbaum RJ, Blaner WS, Ramakrishnan R. A dose-response study of the effects of dietary cholesterol on fasting and postprandial lipid and lipoprotein metabolism in healthy young men. Arterioscler Thromb. 1994 Apr;14(4):576–586. [PMC free article] [PubMed]
  • Khachik F, Bernstein PS, Garland DL. Identification of lutein and zeaxanthin oxidation products in human and monkey retinas. Invest Ophthalmol Vis Sci. 1997 Aug;38(9):1802–1811. [PubMed]

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