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Philos Trans R Soc Lond B Biol Sci. Apr 29, 2003; 358(1432): 787–795.
PMCID: PMC1693163
Genetic neuroscience of mammalian learning and memory.
Susumu Tonegawa, Kazu Nakazawa, and Matthew A Wilson
Picower Center for Learning and Memory, Howard Hughes Medical Institute, and RIKEN-MIT Neuroscience Research Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Our primary research interest is to understand the molecular and cellular mechanisms on neuronal circuitry underlying the acquisition, consolidation and retrieval of hippocampus-dependent memory in rodents. We study these problems by producing genetically engineered (i.e. spatially targeted and/or temporally restricted) mice and analysing these mice by multifaceted methods including molecular and cellular biology, in vitro and in vivo physiology and behavioural studies. We attempt to identify deficits at each of the multiple levels of complexity in specific brain areas or cell types and deduce those deficits that underlie specific learning or memory. We will review our recent studies on the acquisition, consolidation and recall of memories that have been conducted with mouse strains in which genetic manipulations were targeted to specific types of cells in the hippocampus or forebrain of young adult mice.
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