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Can Vet J. 1989 July; 30(7): 577–580.
PMCID: PMC1681086

A retrospective study of the relationship between clinical signs and severity of acidosis in diarrheic calves


A retrospective study of 123 calves under two months of age with signs of diarrhea was performed to investigate the relationships among the calf's demeanor, dehydration, rectal temperature, and base deficit. The severity of dehydration, hypothermia, and metabolic acidosis were associated with level of depression. Clinical signs and age of calf could be used to predict the severity of acidosis. Acidosis was more severe in calves over eight days of age and also increased in severity with the degree of depression. The most severe metabolic acidosis was seen in calves over eight days of age presented in sternal or lateral recumbency; the base deficit in these groups was 16.3 ± 8.3 (means ± 1SD) and 20.3 ± 10.1 mmol/L respectively, and on average these calves require 2.4 and 3.0 L respectively of 1.3% sodium bicarbonate solution to correct the acidosis.

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Selected References

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  • Zugerman C. Diagnosis and management of skin cancer. Compr Ther. 1991 Dec;17(12):17–22. [PubMed]
  • Kasari TR, Naylor JM. Clinical evaluation of sodium bicarbonate, sodium L-lactate, and sodium acetate for the treatment of acidosis in diarrheic calves. J Am Vet Med Assoc. 1985 Aug 15;187(4):392–397. [PubMed]
  • Booth AJ, Naylor JM. Correction of metabolic acidosis in diarrheal calves by oral administration of electrolyte solutions with or without bicarbonate. J Am Vet Med Assoc. 1987 Jul 1;191(1):62–68. [PubMed]
  • FISHER EW. DEATH IN NEONATAL CALF DIARRHOEA. Br Vet J. 1965 Mar;121:132–138. [PubMed]
  • Lewis LD, Phillips RW. Pathophysiologic changes due to coronavirus-induced diarrhea in the calf. J Am Vet Med Assoc. 1978 Sep 1;173(5 Pt 2):636–642. [PubMed]
  • Advances in peritoneal dialysis. Eleventh Annual Conference on Peritoneal Dialysis. Nashville, Tennessee, February 1991. Adv Perit Dial. 1991;7:1–305. [PubMed]
  • Madison DV, Schuman EM. LTP, post or pre? A look at the evidence for the locus of long-term potentiation. New Biol. 1991 Jun;3(6):549–557. [PubMed]
  • Haskins SC. An overview of acid-base physiology. J Am Vet Med Assoc. 1977 Feb 15;170(4):423–428. [PubMed]
  • Kasari TR, Naylor JM. Further studies on the clinical features and clinicopathological findings of a syndrome of metabolic acidosis with minimal dehydration in neonatal calves. Can J Vet Res. 1986 Oct;50(4):502–508. [PMC free article] [PubMed]
  • Naylor JM, Forsyth GW. The alkalinizing effects of metabolizable bases in the healthy calf. Can J Vet Res. 1986 Oct;50(4):509–516. [PMC free article] [PubMed]
  • Radostits OM. Treatment and control of neonatal diarrhea in calves. J Dairy Sci. 1975 Mar;58(3):464–470. [PubMed]

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