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Can Vet J. 1985 July; 26(7): 218, 219-220.
PMCID: PMC1680092

Antibodies Against Equine Herpesvirus 1 in the Cerebrospinal Fluid in the Horse


Neutralizing antibodies against equine herpesvirus 1 were measured in serum and cerebrospinal fluid of 16 horses and ponies from a closed herd both before and after vaccination with modified live equine herpesvirus 1. These titers were also measured in 22 neurologically normal and 15 neurologically abnormal horses at a teaching hospital. Animals from the closed herd had prevaccination serum titers up to 1:8 and postvaccination serum titers up to 1:128. Horses from the teaching hospital had serum titers up to 1:64. Cerebrospinal fluid titers were not detected in the vaccinated horses or the neurologically normal horses but a low titer (1:8) was noted in one neurologically abnormal horse. This titer probably resulted from hemorrhage into the cerebrospinal fluid following trauma.

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Selected References

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  • Petzoldt K, Luttmann U, Pohlenz J, Teichert U. Virologische Untersuchungen des Zentralnervensystems von Pferdefeten und Befunde bei zentralnervös erkrankten Stuten nach Aborten durch das Equine Herpesvirus 1. Schweiz Arch Tierheilkd. 1972 Feb;114(2):129–139. [PubMed]
  • Little PB, Thorsen J. Disseminated necrotizing myeloencephalitis: a herpes-associated neurological disease of horses. Vet Pathol. 1976;13(3):161–171. [PubMed]
  • Dinter Z, Klingeborn B. Serological study of an outbreak of paresis due to equid herpesvirus 1 (EHV-1). Vet Rec. 1976 Jul 3;99(1):10–12. [PubMed]
  • Thomson GW, McCready R, Sanford E, Gagnon A. Case report: An outbreak of herpesvirus myeloencephalitis in vaccinated horses. Can Vet J. 1979 Jan;20(1):22–25. [PMC free article] [PubMed]
  • Pursell AR, Sangster LT, Byars TD, Divers TJ, Cole JR., Jr Neurologic disease induced by equine herpesvirus 1. J Am Vet Med Assoc. 1979 Sep 1;175(5):473–474. [PubMed]
  • Crowhurst FA, Dickinson G, Burrows R. An outbreak of paresis in mares and geldings associated with equid herpesvirus 1. Vet Rec. 1981 Dec 12;109(24):527–528. [PubMed]
  • Jackson T, Kendrick JW. Paralysis of horses associated with equine herpesvirus 1 infection. J Am Vet Med Assoc. 1971 Apr 15;158(8):1351–1357. [PubMed]
  • Jackson TA, Osburn BI, Cordy DR, Kendrick JW. Equine herpesvirus 1 infection of horses: studies on the experimentally induced neurologic disease. Am J Vet Res. 1977 Jun;38(6):709–719. [PubMed]
  • Platt H, Singh H, Whitwell KE. Pathological observations on an outbreak of paralysis in broodmares. Equine Vet J. 1980 Jul;12(3):118–126. [PubMed]
  • Mayhew IG, deLahunta A, Whitlock RH, Krook L, Tasker JB. Spinal cord disease in the horse. Cornell Vet. 1978 Jan;68 (Suppl 6):1–207. [PubMed]
  • Nahmias AJ, Whitley RJ, Visintine AN, Takei Y, Alford CA., Jr Herpes simplex virus encephalitis: laboratory evaluations and their diagnostic significance. J Infect Dis. 1982 Jun;145(6):829–836. [PubMed]
  • Dutta SK, Shipley WD. Immunity and the level of neutralization antibodies in foals and mares vaccinated with a modified live-virus rhinopneumonitis vaccine. Am J Vet Res. 1975 Apr;36(4 PT1):445–448. [PubMed]
  • Purdy CW, Ford SJ, Porter RC. Equine rhinopneumonitis vaccine: immunogenicity and safety in adult horses, including pregnant mares. Am J Vet Res. 1978 Mar;39(3):377–383. [PubMed]
  • Tourtellotte W. On cerebrospinal fluid immunoglobulin-G (IgG) quotients in multiple sclerosis and other diseases. A review and a new formula to estimate the amount of IgG synthesized per day by the central nervous system. J Neurol Sci. 1970 Mar;10(3):279–304. [PubMed]
  • McGuire TC, Crawford TB, Henson JB. Prevalence of antibodies to herpesvirus types 1 and 2, arteritis and infectious anemia viral antigens in equine serum. Am J Vet Res. 1974 Feb;35(2):181–185. [PubMed]

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