Search tips
Search criteria 


Logo of brmedjLink to Publisher's site
Br Med J. 1975 June 14; 2(5971): 583–585.
PMCID: PMC1673535

This article has been retractedRetraction in: BMJ. 2015 October 28; 351: h5682    See also: PMC Retraction Policy

Reduced secretory antibody response to live attenuated measles and poliovirus vaccines in malnourished children.


Serum and nasopharyngeal IgA antibody levels were estimated in 20 malnourished children and 20 matched healthy controls after immunization with a single dose of live attenuated measles or poliovirus vaccine. Seroconversion and serum neutralizing antibody titres were comparable in the two groups. Secretory IgA antibody was detected significantly less often in undernourished children; the time of its first appearance was delayed-and its maximum level was significantly lower. Impaired secretory antibody response in malnourished children may contribute to slow inadequate recovery from viral and enterobacterial infections and predispose to lifethreatening complications.

Full text

Full text is available as a scanned copy of the original print version. Click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Chandra RK. Immunocompetence in undernutrition. J Pediatr. 1972 Dec;81(6):1194–1200. [PubMed]
  • Harland PS. Tuberculin reactions in malnourished children. Lancet. 1965 Oct 9;2(7415):719–721. [PubMed]
  • Geefhuysen J, Rosen EU, Katz J, Ipp T, Metz J. Impaired cellular immunity in kwashiorkor with improvement after therapy. Br Med J. 1971 Nov 27;4(5786):527–529. [PMC free article] [PubMed]
  • Smythe PM, Brereton-Stiles GG, Grace HJ, Mafoyane A, Schonland M, Coovadia HM, Loening WE, Parent MA, Vos GH. Thymolymphatic deficiency and depression of cell-mediated immunity in protein-calorie malnutrition. Lancet. 1971 Oct 30;2(7731):939–943. [PubMed]
  • Antia AU, McFarlane H, Soothill JF. Serum siderophilin in kwashiorkor. Arch Dis Child. 1968 Aug;43(230):459–462. [PMC free article] [PubMed]
  • Seth V, Chandra RK. Opsonic activity, phagocytosis, and bactericidal capacity of polymorphs in undernutrition. Arch Dis Child. 1972 Apr;47(252):282–284. [PMC free article] [PubMed]
  • Selvaraj RJ, Bhat KS. [Metabolic and bactericidal activities of leukocytes in protein-calorie malnutrition]. Am J Clin Nutr. 1972 Feb;25(2):166–174. [PubMed]
  • Douglas SD, Schopfer K. Phagocyte function in protein-calorie malnutrition. Clin Exp Immunol. 1974 May;17(1):121–128. [PubMed]
  • Chandra RK. Serum complement and immunoconglutinin in malnutrition. Arch Dis Child. 1975 Mar;50(3):225–229. [PMC free article] [PubMed]
  • Sirisinha S, Edelman R, Suskind R, Charupatana C, Olson RE. Complement and C3-proactivator levels in children with protein-calorie malnutrition and effect of dietary treatment. Lancet. 1973 May 12;1(7811):1016–1020. [PubMed]
  • Taylor B, Norman AP, Orgel HA, Stokes CR, Turner MW, Soothill JF. Transient IgA deficiency and pathogenesis of infantile atopy. Lancet. 1973 Jul 21;2(7821):111–113. [PubMed]
  • Chandra RK, Sharma S, Bhujwala RA. Effect of acute and chronic starvation on plaque forming cell response in mice. Indian J Med Res. 1973 Jan;61(1):93–97. [PubMed]
  • Chandra RK. Letter: Immunocompetence in low-birth-weight infants after intrauterine malnutrition. Lancet. 1974 Dec 7;2(7893):1393–1394. [PubMed]
  • Chandra RK. Fetal malnutrition and postnatal immunocompetence. Am J Dis Child. 1975 Apr;129(4):450–454. [PubMed]

Articles from British Medical Journal are provided here courtesy of BMJ Publishing Group