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Skull base surgery. 1995 April; 5(2): 123–129.
PMCID: PMC1661818

Head and Neck Squamous Cell Carcinoma Metastatic to the Orbital Apex


Primary squamous cell carcinoma of the head and neck most commonly metastasizes to the lymph nodes, lung, bone, and liver. Many other rare sites of metastatic disease have been reported. To date, metastatic squamous cell carcinoma of the head and neck to the orbital apex has not been described. Presented are two cases, one tonsil and one parotid primary with metastatic disease to the orbital apex. Many tumors have been found to metastasize to the eye and orbit, but head and neck neoplasms are rarely reported. A review of the literature is presented in addition to the detailed case reports with their radiologic findings and clinical course. Surgical resection followed by postoperative radiotherapy appears the treatment of choice at this time.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Kotwall C, Sako K, Razack MS, Rao U, Bakamjian V, Shedd DP. Metastatic patterns in squamous cell cancer of the head and neck. Am J Surg. 1987 Oct;154(4):439–442. [PubMed]
  • Conley J. The risk to the orbit in head and neck cancer. Laryngoscope. 1985 May;95(5):515–522. [PubMed]
  • Ferry AP, Font RL. Carcinoma metastatic to the eye and orbit. I. A clinicopathologic study of 227 cases. Arch Ophthalmol. 1974 Oct;92(4):276–286. [PubMed]
  • Font RL, Ferry AP. Carcinoma metastatic to the eye and orbit III. A clinicopathologic study of 28 cases metastatic to the orbit. Cancer. 1976 Sep;38(3):1326–1335. [PubMed]
  • Osguthorpe JD, Saunders RA, Adkins WY. Evaluation of and access to posterior orbital tumors. Laryngoscope. 1983 Jun;93(6):766–771. [PubMed]
  • Maroon JC, Kennerdell JS. Surgical approaches to the orbit. Indications and techniques. J Neurosurg. 1984 Jun;60(6):1226–1235. [PubMed]
  • Kaplan MJ, Jane JA, Park TS, Cantrell RW. Supraorbital rim approach to the anterior skull base. Laryngoscope. 1984 Sep;94(9):1137–1139. [PubMed]
  • Leone CR, Jr, Wissinger JP. Surgical approaches to diseases of the orbital apex. Ophthalmology. 1988 Mar;95(3):391–397. [PubMed]
  • Osguthorpe JD. Surgical access to primary orbital tumors. Otolaryngol Clin North Am. 1988 Feb;21(1):135–153. [PubMed]
  • Shields JA, Bakewell B, Augsburger JJ, Flanagan JC. Classification and incidence of space-occupying lesions of the orbit. A survey of 645 biopsies. Arch Ophthalmol. 1984 Nov;102(11):1606–1611. [PubMed]
  • Jensen OA. Metastatic tumours of the eye and orbit. A histopathological analysis of a Danish series. Acta Pathol Microbiol Scand Suppl. 1970;212(Suppl):201+–201+. [PubMed]
  • Ferry AP, Font RL. Carcinoma metastatic to the orbit. Mod Probl Ophthalmol. 1975;14:377–381. [PubMed]
  • Tijl J, Koornneef L, Eijpe A, Thomas L, Gonzalez DG, Veenhof C. Metastatic tumors to the orbit--management and prognosis. Graefes Arch Clin Exp Ophthalmol. 1992;230(6):527–530. [PubMed]
  • Wright J, Morgan G. Squamous cell carcinoma developing in an orbital cyst. Arch Ophthalmol. 1977 Apr;95(4):635–637. [PubMed]
  • BERKE RN. A modified Krönlein operation. Trans Am Ophthalmol Soc. 1953;51:193–231. [PMC free article] [PubMed]
  • Maroon JC, Kennerdel JS. Lateral microsurgical approach to intraorbital tumors. J Neurosurg. 1976 May;44(5):556–561. [PubMed]

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