PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of skullbaseInstructions for AuthorsSubscribe to Skull BaseAbout Skull BaseEditorial BoardThieme Medical PublishingSkull Base An Interdisciplinary Approach ...
 
Skull Base. 2002 May; 12(2): 87–91.
PMCID: PMC1656915

Second Malignant Tumors After Treatment of Nasopharyngeal Carcinoma

Four Case Reports and Literature Review

Abstract

The purpose of this study was to identify the histopathology, location, and latency interval for the development of second malignant tumors (SMT) after successful treatment for nasopharyngeal carcinoma (NPC). Of 55 patients, four developed SMT after successful treatment of NPC in a single institutional series for an incidence of 7%. An additional 31 patients with SMT after treatment for NPC were identified from the literature. At minimum, all patients were treated with radiotherapy to the primary site. The histopathology of SMT included sarcoma (69%), squamous cell carcinoma (17%), adenocarcinoma (6%), meningioma (6%), and lymphoma (3%). SMT occurred at various sites in the head and neck, but most (51%) arose in the sinonasal cavity. For the entire group, the mean latency interval between treatment for NPC and the development of SMT was 11.8 years. These findings indicate that the development of SMT in patients achieving long-term survival after treatment for NPC may be radiation induced. Long-term follow-up for these patients is important to assess for this potentially late complication.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (662K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Chan AT, Teo PM, Leung TW, Johnson PJ. The role of chemotherapy in the management of nasopharyngeal carcinoma. Cancer. 1998 Mar 15;82(6):1003–1012. [PubMed]
  • Muir CS. Nasopharyngeal carcinoma in non-Chinese populations with special reference to south-east Asia and Africa. Int J Cancer. 1971 Nov 15;8(3):351–363. [PubMed]
  • Vasef MA, Ferlito A, Weiss LM. Nasopharyngeal carcinoma, with emphasis on its relationship to Epstein-Barr virus. Ann Otol Rhinol Laryngol. 1997 Apr;106(4):348–356. [PubMed]
  • Al-Sarraf M, LeBlanc M, Giri PG, Fu KK, Cooper J, Vuong T, Forastiere AA, Adams G, Sakr WA, Schuller DE, et al. Chemoradiotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer: phase III randomized Intergroup study 0099. J Clin Oncol. 1998 Apr;16(4):1310–1317. [PubMed]
  • Kotwall C, Razack MS, Sako K, Rao U. Multiple primary cancers in squamous cell cancer of the head and neck. J Surg Oncol. 1989 Feb;40(2):97–99. [PubMed]
  • Ingersoll L, Woo SY, Donaldson S, Giesler J, Maor MH, Goffinet D, Cangir A, Goepfert H, Oswald MJ, Peters LJ. Nasopharyngeal carcinoma in the young: a combined M.D. Anderson and Stanford experience. Int J Radiat Oncol Biol Phys. 1990 Oct;19(4):881–887. [PubMed]
  • Stein ME, Drumea K, Bernstein Z, Daoud C, Zarour M, Kuten A. Advanced nasopharyngeal carcinoma and radiation-induced meningioma in dizygotic twins--a rare case report. Acta Oncol. 1996;35(6):761–762. [PubMed]
  • Wang EH, Sekyi-Otu A, O'Sullivan B, Bell RS. Management of long-term postirradiation periclavicular complications. J Surg Oncol. 1992 Dec;51(4):259–265. [PubMed]
  • Lee AW, Law SC, Ng SH, Chan DK, Poon YF, Foo W, Tung SY, Cheung FK, Ho JH. Retrospective analysis of nasopharyngeal carcinoma treated during 1976-1985: late complications following megavoltage irradiation. Br J Radiol. 1992 Oct;65(778):918–928. [PubMed]
  • Dickens P, Wei WI, Sham JS. Osteosarcoma of the maxilla in Hong Kong Chinese postirradiation for nasopharyngeal carcinoma. A report of four cases. Cancer. 1990 Nov 1;66(9):1924–1926. [PubMed]
  • John AC, Busby ER, Jones PH. Long-term survival in nasopharyngeal carcinoma. J Laryngol Otol. 1980 Nov;94(11):1265–1275. [PubMed]
  • Ayan I, Altun M. Nasopharyngeal carcinoma in children: retrospective review of 50 patients. Int J Radiat Oncol Biol Phys. 1996 Jun 1;35(3):485–492. [PubMed]
  • Sheen TS, Wu CT, Hsieh T, Hsu MM. Postirradiation laryngeal osteosarcoma: case report and literature review. Head Neck. 1997 Jan;19(1):57–62. [PubMed]
  • Ko JY, Chen CL, Lui LT, Hsu MM. Radiation-induced malignant fibrous histiocytoma in patients with nasopharyngeal carcinoma. Arch Otolaryngol Head Neck Surg. 1996 May;122(5):535–538. [PubMed]
  • Papavasiliou C, Kouvaris J, Athanasiadis P, Patrinou A, Deligeorgi H. Mandibular sarcoma as a second neoplasm following radiotherapy for a nasopharyngeal carcinoma in childhood (case report). Radiother Oncol. 1987 Apr;8(4):333–335. [PubMed]
  • Tan BC, Chia KB. Radiation induced cancer: a report of 10 cases. Ann Acad Med Singapore. 1981 Jul;10(3):267–276. [PubMed]
  • Lin SK, How SW, Wang JT, Liu BY, Chiang CP. Oral post-radiation malignant fibrous histiocytoma: a clinicopathological study. J Oral Pathol Med. 1994 Aug;23(7):324–329. [PubMed]
  • Cooper JS, Scott C, Marcial V, Griffin T, Fazekas J, Laramore G, Hoffman A. The relationship of nasopharyngeal carcinomas and second independent malignancies based on the Radiation Therapy Oncology Group experience. Cancer. 1991 Mar 15;67(6):1673–1677. [PubMed]
  • Modan B, Baidatz D, Mart H, Steinitz R, Levin SG. Radiation-induced head and neck tumours. Lancet. 1974 Feb 23;1(7852):277–279. [PubMed]
  • Qian TN, Huang YR, Gu XZ. Radiation induced cancer. Int J Radiat Oncol Biol Phys. 1983 Aug;9(8):1246–1246. [PubMed]
  • Wang CC, Chen ML, Hsu KH, Lee SP, Chen TC, Chang YS, Tsang NM, Hong JH. Second malignant tumors in patients with nasopharyngeal carcinoma and their association with Epstein-Barr virus. Int J Cancer. 2000 Jul 15;87(2):228–231. [PubMed]

Articles from Skull Base are provided here courtesy of Thieme Medical Publishers