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Skull Base. 2002 May; 12(2): 59–65.
PMCID: PMC1656909

Skull Base Neurocytoma

Case Report and Review of the Literature of Extraventricular Neurocytomas

Abstract

We report a rare skull base neurocytoma. A 44-year-old female with a history of focal seizure and progressive right-sided weakness sought treatment at an outside institution, where she underwent total resection of a “left medial sphenoid wing paraganglioma” in 1984. In 1995 after experiencing intense left-sided headaches for 3 weeks, the patient presented to our institution. Magnetic resonance imaging revealed a large local recurrence. She had deficits dating to her initial surgery, including moderate right-sided hemiparesis, complete left ophthalmoplegia, and left facial numbness.

The patient underwent a craniotomy with extensive removal of the involved sphenoid bone and a subtotal resection of the tumor. Neurocytoma was diagnosed based on strong immunohistochemical staining for synaptophysin and no reactivity for glial fibrillary acidic protein. Postoperatively, her headaches resolved completely and her neurologic status remained at baseline. The residual tumor was treated with radiation therapy. After 5 years, she remains clinically and radiographically stable.

Although typically located adjacent to the foramen of Monro, neurocytomas have now been reported in almost every subcompartment of the craniospinal axis. Finding neurocytomas in extraventricular locations may require revisiting the current theory that subependymal progenitor cells are the cells of origin for these tumors.

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Selected References

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  • Hassoun J, Gambarelli D, Grisoli F, Pellet W, Salamon G, Pellissier JF, Toga M. Central neurocytoma. An electron-microscopic study of two cases. Acta Neuropathol. 1982;56(2):151–156. [PubMed]
  • Kleihues P, Burger PC, Scheithauer BW. The new WHO classification of brain tumours. Brain Pathol. 1993 Jul;3(3):255–268. [PubMed]
  • Hassoun J, Söylemezoglu F, Gambarelli D, Figarella-Branger D, von Ammon K, Kleihues P. Central neurocytoma: a synopsis of clinical and histological features. Brain Pathol. 1993 Jul;3(3):297–306. [PubMed]
  • Kim DG, Chi JG, Park SH, Chang KH, Lee SH, Jung HW, Kim HJ, Cho BK, Choi KS, Han DH. Intraventricular neurocytoma: clinicopathological analysis of seven cases. J Neurosurg. 1992 May;76(5):759–765. [PubMed]
  • Hara A, Araki Y, Shinoda J, Hirayama H, Niikawa S, Sakai N, Yamada H. Central neurocytoma: proliferative assessment by nucleolar organizer region staining. Surg Neurol. 1993 May;39(5):343–347. [PubMed]
  • Nishio S, Takeshita I, Kaneko Y, Fukui M. Cerebral neurocytoma. A new subset of benign neuronal tumors of the cerebrum. Cancer. 1992 Jul 15;70(2):529–537. [PubMed]
  • Hessler RB, Lopes MB, Frankfurter A, Reidy J, VandenBerg SR. Cytoskeletal immunohistochemistry of central neurocytomas. Am J Surg Pathol. 1992 Nov;16(11):1031–1038. [PubMed]
  • Figarella-Branger D, Pellissier JF, Daumas-Duport C, Delisle MB, Pasquier B, Parent M, Gambarelli D, Rougon G, Hassoun J. Central neurocytomas. Critical evaluation of a small-cell neuronal tumor. Am J Surg Pathol. 1992 Feb;16(2):97–109. [PubMed]
  • Yasargil MG, von Ammon K, von Deimling A, Valavanis A, Wichmann W, Wiestler OD. Central neurocytoma: histopathological variants and therapeutic approaches. J Neurosurg. 1992 Jan;76(1):32–37. [PubMed]
  • Sgouros S, Jackowski A, Carey MP. Central neurocytoma without intraventricular extension. Surg Neurol. 1994 Oct;42(4):335–339. [PubMed]
  • Coca S, Moreno M, Martos JA, Rodriguez J, Barcena A, Vaquero J. Neurocytoma of spinal cord. Acta Neuropathol. 1994;87(5):537–540. [PubMed]
  • Louis DN, Swearingen B, Linggood RM, Dickersin GR, Kretschmar C, Bhan AK, Hedley-Whyte ET. Central nervous system neurocytoma and neuroblastoma in adults--report of eight cases. J Neurooncol. 1990 Dec;9(3):231–238. [PubMed]
  • Stapleton SR, David KM, Harkness WF, Harding BN. Central neurocytoma of the cervical spinal cord. J Neurol Neurosurg Psychiatry. 1997 Jul;63(1):119–119. [PMC free article] [PubMed]
  • Stephan CL, Kepes JJ, Arnold P, Green KD, Chamberlin F. Neurocytoma of the cauda equina. Case report. J Neurosurg. 1999 Apr;90(2 Suppl):247–251. [PubMed]
  • Hirschowitz L, Ansari A, Cahill DJ, Bamford DS, Love S. Central neurocytoma arising within a mature cystic teratoma of the ovary. Int J Gynecol Pathol. 1997 Apr;16(2):176–179. [PubMed]
  • Giangaspero F, Cenacchi G, Losi L, Cerasoli S, Bisceglia M, Burger PC. Extraventricular neoplasms with neurocytoma features. A clinicopathological study of 11 cases. Am J Surg Pathol. 1997 Feb;21(2):206–212. [PubMed]
  • Enam SA, Rosenblum ML, Ho KL. Neurocytoma in the cerebellum. Case report. J Neurosurg. 1997 Jul;87(1):100–102. [PubMed]
  • Sgouros S, Walsh AR, Barber P. Central neurocytoma of thalamic origin. Br J Neurosurg. 1994;8(3):373–376. [PubMed]
  • Soontornniyomkij V, Schelper RI. Pontine neurocytoma. J Clin Pathol. 1996 Sep;49(9):764–765. [PMC free article] [PubMed]
  • Metcalf C, Mele EM, McAllister I. Neurocytoma of the retina. Br J Ophthalmol. 1993 Jun;77(6):382–384. [PMC free article] [PubMed]
  • von Deimling A, Kleihues P, Saremaslani P, Yasargil MG, Spoerri O, Südhof TC, Wiestler OD. Histogenesis and differentiation potential of central neurocytomas. Lab Invest. 1991 Apr;64(4):585–591. [PubMed]
  • Nishio S, Takeshita I, Fukui M. Primary cerebral ganglioneurocytoma in an adult. Cancer. 1990 Jul 15;66(2):358–362. [PubMed]
  • Alkhani AM, Bilbao JM, Medline P, Ogundimu FA. Ganglioglioneurocytoma of the posterior fossa. Can J Neurol Sci. 1999 Aug;26(3):207–210. [PubMed]
  • Schweitzer JB, Davies KG. Differentiating central neurocytoma. Case report. J Neurosurg. 1997 Mar;86(3):543–546. [PubMed]
  • Tatter SB, Borges LF, Louis DN. Central neurocytomas of the cervical spinal cord. Report of two cases. J Neurosurg. 1994 Aug;81(2):288–293. [PubMed]
  • Harada M, Morioka T, Nishio S, Fukui M. [Neurocytoma in the left frontal lobe]. No Shinkei Geka. 1991 Jan;19(1):89–92. [PubMed]

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