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Skull base surgery. 1999; 9(3): 207–210.
PMCID: PMC1656741

Effects of Bilateral Jugular Vein Ligation on Local Cerebral Blood Flow


The authors examined the effect of bilateral jugular vein ligation (JVL) on local cerebral blood flow (CBF). Local CBF was measured in the neocortex of the frontal lobe over a 1-week period in 10 freely moving male rats. Measurements were taken with the hydrogen clearance method before and after the rat underwent either an operation of bilateral JVL or a sham operation. After the sham operation, blood flow values did not change significantly compared with preoperative values. Blood flow values decreased rapidly in rats with JVL. For 3 hours after surgery, JVL values were significantly lower (p <0.05) than preoperative values were, then gradually they recovered and reached preoperative values within 48 hours. Histopathologic study showed no remarkable parenchymal damages in the brain of rats with JVL. These results show that bilateral JVL produces a reversible decrease in the CBF and does not cause histopathologic brain damages.

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Selected References

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  • Razack MS, Baffi R, Sako K. Bilateral radical neck dissection. Cancer. 1981 Jan 1;47(1):197–199. [PubMed]
  • Yung MW, Soliman AM. Changes in the brainstem evoked responses following jugular vein ligation. J Laryngol Otol. 1988 Oct;102(10):861–864. [PubMed]
  • Kawajiri H, Furuse M, Namba R, Kotani J, Oka T. Effect of internal jugular vein ligation on resorption of cerebrospinal fluid. J Maxillofac Surg. 1983 Feb;11(1):42–45. [PubMed]
  • Kotani J, Nitta K, Sakuma Y, Sugioka S, Fujita N, Ueda Y. Effects of bilateral jugular vein ligation on intracranial pressure and cerebrospinal fluid outflow resistance in cats. Br J Oral Maxillofac Surg. 1992 Jun;30(3):171–173. [PubMed]
  • Hasan M, Srimal RC, Maitra SC. Bilateral jugular vein ligation-induced alterations in the ventricular ependyma: scanning electron microscopy. Int Surg. 1980 Nov-Dec;65(6):533–540. [PubMed]
  • Yura S, Sako K, Yonemasu Y. [The effects of disturbance of cerebral venous drainage on focal cerebral blood flow and ischemic cerebral edema]. No To Shinkei. 1990 Mar;42(3):269–275. [PubMed]
  • Endo Y, Jinnai K, Endo M, Fujita K, Kimura F. Diurnal variation of cerebral blood flow in rat hippocampus. Stroke. 1990 Oct;21(10):1464–1469. [PubMed]
  • Endo Y, Nishimura J, Kimura F. Adrenalectomy increases local cerebral blood flow in the rat hippocampus. Pflugers Arch. 1994 Feb;426(3-4):183–188. [PubMed]
  • Nishimura J, Endo Y, Kimura F. Increases in cerebral blood flow in rat hippocampus after medial septal injection of naloxone. Stroke. 1992 Sep;23(9):1325–1330. [PubMed]
  • GIUS JA, GRIER DH. Venous adaptation following bilateral radical neck dissection with excision of the jugular veins. Surgery. 1950 Aug;28(2):305–321. [PubMed]
  • ROYSTER HP. The relation between internal jugular vein pressure and cerebrospinal fluid pressure in the operation of radical neck dissection. Ann Surg. 1953 Jun;137(6):826–832. [PubMed]
  • JONES RK. Increased intracranial pressure following radical neck surgery. AMA Arch Surg. 1951 Nov;63(5):599–603. [PubMed]
  • SCHWEIZER O, LEAK GH. A study of spinal fluid pressures in operations requiring removal of both internal jugular veins. Ann Surg. 1952 Dec;136(6):948–956. [PubMed]
  • de Vries WA, Balm AJ, Tiwari RM. Intracranial hypertension following neck dissection. J Laryngol Otol. 1986 Dec;100(12):1427–1431. [PubMed]
  • Chai PJ, Skaryak LA, Ungerleider RM, Greeley WJ, Kern FH, Schulman SR, Hansell DR, Auten RL, Mahaffey SF, Meliones JN. Jugular ligation does not increase intracranial pressure but does increase bihemispheric cerebral blood flow and metabolism. Crit Care Med. 1995 Nov;23(11):1864–1871. [PubMed]

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