PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of skullbasesurgInstructions for AuthorsSubscribe to Skull BaseAbout Skull BaseEditorial BoardThieme Medical PublishingSkull Base An Interdisciplinary Approach ...
 
Skull base surgery. 1998; 8(2): 93–97.
PMCID: PMC1656693

Giant Cell Tumor of the Sphenoid Bone*

Abstract

Objective and Importance: Giant cell tumor of the sphenoid bone is extremely unusual. This tumor is usually located in long bones and is rarely located in the cranial vault. It must be differentiated from reparative granuloma and the Brown tumor of hyperparathyroidism. This case report is only the second involving a patient in the first decade.

Clinical Presentation: A 9-year-old girl presented with cephalgia and diplopia. Radiographic imaging revealed an erosive mass in the clivus.

Intervention: The patient underwent an extended transphenoidal resection of the clivus. This was followed with 57.6 CGE in 32 fractionated doses.

Conclusion: At 1 year follow-up, the tumor remains stable. Based on anecdotal evidence, attempted resection with adjuvant radiation therapy allows for long-term survival in these patients.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (2.0M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • WILLIAMS RR, DAHLIN DC, GHORMLEY RK. Giant-cell tumor of bone. Cancer. 1954 Jul;7(4):764–773. [PubMed]
  • Goldenberg RR, Campbell CJ, Bonfiglio M. Giant-cell tumor of bone. An analysis of two hundred and eighteen cases. J Bone Joint Surg Am. 1970 Jun;52(4):619–664. [PubMed]
  • Pitkethly DT, Kempe LG. Giant cell tumors of the sphenoid. Report of two cases. J Neurosurg. 1969 Mar;30(3):301–304. [PubMed]
  • Wolfe JT, 3rd, Scheithauer BW, Dahlin DC. Giant-cell tumor of the sphenoid bone. Review of 10 cases. J Neurosurg. 1983 Aug;59(2):322–327. [PubMed]
  • Geissger JD, Siqueira EB, Ross ER. Giant cell tumors of the sphenoid bone. J Neurosurg. 1970 Jun;32(6):665–670. [PubMed]
  • Watkins LD, Uttley D, Archer DJ, Wilkins P, Plowman N. Giant cell tumors of the sphenoid bone. Neurosurgery. 1992 Apr;30(4):576–581. [PubMed]
  • Vernet O, Ducrey N, Déruaz JP, de Tribolet N. Giant cell tumor of the orbit. Neurosurgery. 1993 May;32(5):848–851. [PubMed]
  • Doshi R, Chaudhari AB, Thomson G. Giant cell tumor of the sphenoid bone. Can J Neurol Sci. 1977 Aug;4(3):213–216. [PubMed]
  • Martins AN, Dean DF. Giant cell tumor of sphenoid bone: malignant transformation following radiotherapy. Surg Neurol. 1974 Mar;2(2):105–107. [PubMed]
  • Ohaegbulam SC, Gupta IM. Giant cell tumour of the sphenoid bone with dural extension. J Neurol Neurosurg Psychiatry. 1977 Aug;40(8):790–794. [PMC free article] [PubMed]
  • Suster S, Porges R, Tobias J, Nanes M. Giant-cell neoplasm of the sphenoid sinus. Mt Sinai J Med. 1989 Mar;56(2):118–122. [PubMed]
  • Carmody RF, Rickles DJ, Johnson SF. Giant cell tumor of the sphenoid bone. J Comput Assist Tomogr. 1983 Apr;7(2):370–373. [PubMed]
  • Harman SA, Pribram H. Case report 586: Giant cell tumor of sphenoid bone. Skeletal Radiol. 1990;19(3):212–215. [PubMed]
  • Kemeny AA, Afshar F. Giant cell tumour of the sphenoid bone with coincidental galactorrhoea--a case report. Br J Neurosurg. 1990;4(4):343–346. [PubMed]
  • Kioumehr F, Rooholamini SA, Yaghmai I, Hoover L, Arnold A, Hannah J, Rodriguez L. Giant-cell tumor of the sphenoid bone: case report and review of the literature. Can Assoc Radiol J. 1990 Jun;41(3):155–157. [PubMed]
  • Ciappetta P, Salvati M, Bernardi C, Raco A, Di Lorenzo N. Giant cell reparative granuloma of the skull base mimicking an intracranial tumor. Case report and review of the literature. Surg Neurol. 1990 Jan;33(1):52–56. [PubMed]
  • Smith GA, Ward PH. Giant-cell lesions of the facial skeleton. Arch Otolaryngol. 1978 Apr;104(4):186–190. [PubMed]
  • Dahlin DC, Cupps RE, Johnson EW., Jr Giant-cell tumor: a study of 195 cases. Cancer. 1970 May;25(5):1061–1070. [PubMed]
  • Potter GD, McClennan BL. Malignant giant cell tumor of the sphenoid bone and its differential diagnosis. Cancer. 1970 Jan;25(1):167–170. [PubMed]
  • Gupta OP, Samant HC, Bhatia PL, Agarwal AK, Pant GC. Giant cell tumor of the spenoid bone. Ann Otol Rhinol Laryngol. 1975 May-Jun;84(3 Pt 1):359–363. [PubMed]

Articles from Skull Base Surgery are provided here courtesy of Thieme Medical Publishers