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Skull base surgery. 1998; 8(1): 45–50.
PMCID: PMC1656655

Fibroinflammatory Pseudotumor of the Temporal Bone


Chronic inflammatory tumor-like lesions of the temporal bone represent a difficult clinical task for the skull base surgeon. Their osteolytic aggressiveness endangers vital structures and may not be controlled by surgery alone. We present the course of four cases of fibroinflammatory pseudotumor of the temporal bone which were treated by a combined approach of skull base surgery and chemotherapy. Three patients were deafened by the disease and underwent several operafive measures. One patient was lost, most likely due to an arrosive bleeding of the internal carotid artery. The chronic and recurrent process could only be stopped by petrosectomy, followed by antiproliferative chemotherapy. Two patients were subsequently provided with a cochlear implant. The differential diagnosis, diagnostic, and operative options of this rare but severe disease are discussed.

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Selected References

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  • Pettinato G, Manivel JC, De Rosa N, Dehner LP. Inflammatory myofibroblastic tumor (plasma cell granuloma). Clinicopathologic study of 20 cases with immunohistochemical and ultrastructural observations. Am J Clin Pathol. 1990 Nov;94(5):538–546. [PubMed]
  • Storck M, Liewald F, Heymer B, Dienemann H, Sunder-Plassmann L. Inflammatorische Pseudotumoren der Lunge und Trachea. Zentralbl Chir. 1995;120(8):650–656. [PubMed]
  • Moran CA, Suster S, Abbondanzo SL. Inflammatory pseudotumor of lymph nodes: a study of 25 cases with emphasis on morphological heterogeneity. Hum Pathol. 1997 Mar;28(3):332–338. [PubMed]
  • Davis RE, Warnke RA, Dorfman RF. Inflammatory pseudotumor of lymph nodes. Additional observations and evidence for an inflammatory etiology. Am J Surg Pathol. 1991 Aug;15(8):744–756. [PubMed]
  • Facchetti F, De Wolf Peeters C, De Wever I, Frizzera G. Inflammatory pseudotumor of lymph nodes. Immunohistochemical evidence for its fibrohistiocytic nature. Am J Pathol. 1990 Aug;137(2):281–289. [PubMed]
  • Williams SB, Foss RD, Ellis GL. Inflammatory pseudotumors of the major salivary glands. Clinicopathologic and immunohistochemical analysis of six cases. Am J Surg Pathol. 1992 Sep;16(9):896–902. [PubMed]
  • Cross DL, Switter DJ. Fibroinflammatory pseudotumor of the submandibular gland. Head Neck. 1996 Sep-Oct;18(5):465–468. [PubMed]
  • Said H, Razi Hadi A, Akmal SN, Lokman S. Tumefactive fibroinflammatory lesion of the head and neck. J Laryngol Otol. 1988 Nov;102(11):1064–1067. [PubMed]
  • Prichard AJ, Colloby P, Barton RP, Heaton JM. Tumefactive fibroinflammatory lesions of the head and neck. J Laryngol Otol. 1990 Oct;104(10):797–800. [PubMed]
  • Aijaz F, Salam AU, Muzaffar S, Akbani Y, Hasan SH. Inflammatory pseudotumour of the trachea: report of a case in an eight-year-old child. J Laryngol Otol. 1994 Jul;108(7):613–616. [PubMed]
  • Hurt MA, Santa Cruz DJ. Cutaneous inflammatory pseudotumor. Lesions resembling "inflammatory pseudotumors" or "plasma cell granulomas" of extracutaneous sites. Am J Surg Pathol. 1990 Aug;14(8):764–773. [PubMed]
  • Laurenzo JF, Graham SM. Tumefactive fibroinflammatory lesion of the head and neck: a management strategy. Ear Nose Throat J. 1995 Feb;74(2):87–94. [PubMed]
  • Nam BH, Rha KS, Yoo JY, Park CI. Plasma cell granuloma of the temporal bone: a case report. Head Neck. 1994 Sep-Oct;16(5):457–459. [PubMed]
  • Benton NC, Korol HW, Smyth LT., Jr Plasma cell granuloma of the middle ear and mastoid. Case report. Ann Otol Rhinol Laryngol. 1992 Jan;101(1):92–94. [PubMed]
  • Mark AS. Contrast-enhanced magnetic resonance imaging of the temporal bone. Neuroimaging Clin N Am. 1994 Feb;4(1):117–131. [PubMed]
  • Holliday RA. Inflammatory diseases of the temporal bone: evaluation with CT and MR. Semin Ultrasound CT MR. 1989 Jun;10(3):213–235. [PubMed]
  • Yoon TH, Paparella MM, Schachern PA. Systemic vasculitis: a temporal bone histopathologic study. Laryngoscope. 1989 Jun;99(6 Pt 1):600–609. [PubMed]
  • Kletzker GR, Smith PG, McIntire LD, Leonetti JP. Presentation and management of uncommon lesions of the middle ear. Am J Otol. 1995 Sep;16(5):634–642. [PubMed]
  • Gacek RR. Evaluation and management of temporal bone arachnoid granulations. Arch Otolaryngol Head Neck Surg. 1992 Mar;118(3):327–332. [PubMed]
  • Meininger GR, Pollice P, Niparko JK. Imaging quiz case 2. Chronic osteomyelitis of the skull base (OSB). Arch Otolaryngol Head Neck Surg. 1997 Mar;123(3):349–352. [PubMed]
  • Kadoya C, Soejima T, Yamada H, Yokota A. Pachymeningoencephalitis: case report. Neurosurgery. 1993 Jul;33(1):131–134. [PubMed]
  • Henick DH, Feghali JG. Bilateral cholesterol granuloma: an unusual presentation as an intradural mass. J Otolaryngol. 1994 Feb;23(1):15–18. [PubMed]
  • Liu FF, Keane TJ, Davidson J. Primary carcinoma involving the petrous temporal bone. Head Neck. 1993 Jan-Feb;15(1):39–43. [PubMed]
  • Watters GW, Brookes GB. Chondrosarcoma of the temporal bone. Clin Otolaryngol Allied Sci. 1995 Feb;20(1):53–58. [PubMed]
  • Wanifuchi N, Ishizuka Y, Yabe T. A case of eosinophilic granuloma in the temporal bone. Auris Nasus Larynx. 1991;18(1):17–26. [PubMed]
  • Donner LR, Trompler RA, White RR., 4th Progression of inflammatory myofibroblastic tumor (inflammatory pseudotumor) of soft tissue into sarcoma after several recurrences. Hum Pathol. 1996 Oct;27(10):1095–1098. [PubMed]

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