Search tips
Search criteria 


Logo of skullbasesurgInstructions for AuthorsSubscribe to Skull BaseAbout Skull BaseEditorial BoardThieme Medical PublishingSkull Base An Interdisciplinary Approach ...
Skull base surgery. 1997; 7(4): 217–221.
PMCID: PMC1656648

Trigeminal Neurotrophic Ulceration


A 74 year-old female developed a trigeminal neurotrophic ulcer (TNU) 20 years following surgical ablation of the trigeminal nerve. The diagnosis of this unusual disorder is suggested when an ulcerative lesion develops. In the ala nasi in a patient with trigeminal sensory loss. A history of self-induced trauma to that area and some form of mental impairment further support the diagnosis.

Exclusion of basal cell carcinoma and other causes of facial ulceration is mandatory before the diagnosis of TNU is established.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (2.1M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Spillane JD, Urich H. Trigeminal neuropathy with nasal ulceration: report of two cases and one necropsy. J Neurol Neurosurg Psychiatry. 1976 Feb;39(2):105–113. [PMC free article] [PubMed]
  • Weintraub E, Soltani K, Hekmatpanah J, Lorincz AL. Trigeminal trophic syndrome. A case and review. J Am Acad Dermatol. 1982 Jan;6(1):52–57. [PubMed]
  • Haensch R. Neurotrophic ulcer associated with the Wallenberg syndrome. Acta Derm Venereol. 1968;48(6):622–629. [PubMed]
  • McKenzie KG. OBSERVATIONS ON THE RESULTS OF THE OPERATIVE TREATMENT OF TRIGEMINAL NEURALGIA. Can Med Assoc J. 1933 Nov;29(5):492–496. [PMC free article] [PubMed]
  • Freeman AG. Trigeminal neuralgia: complications of its surgical treatment. Br Med J. 1967 Mar 11;1(5540):631–632. [PMC free article] [PubMed]
  • Henderson WR. Trigeminal neuralgia: the pain and its treatment. Br Med J. 1967 Jan 7;1(5531):7–15. [PMC free article] [PubMed]
  • Walton S, Keczkes K. Trigeminal neurotrophic ulceration--a report of four patients. Clin Exp Dermatol. 1985 Sep;10(5):485–490. [PubMed]
  • Bauer F. Trophic ulceration of the ala nasi following trigeminal denervation. J Laryngol Otol. 1966 Apr;80(4):422–425. [PubMed]
  • HOWELL JB. Neurotrophic changes in the trigeminal territory. Disturbances after operation for trigeminal neuralgia. Arch Dermatol. 1962 Oct;86:442–449. [PubMed]
  • Ho FC, Choy D, Loke SL, Kung IT, Fu KH, Liang R, Todd D, Khoo RK. Polymorphic reticulosis and conventional lymphomas of the nose and upper aerodigestive tract: a clinicopathologic study of 70 cases, and immunophenotypic studies of 16 cases. Hum Pathol. 1990 Oct;21(10):1041–1050. [PubMed]
  • Medeiros LJ, Peiper SC, Elwood L, Yano T, Raffeld M, Jaffe ES. Angiocentric immunoproliferative lesions: a molecular analysis of eight cases. Hum Pathol. 1991 Nov;22(11):1150–1157. [PubMed]
  • Westerhof W, Bos JD. Trigeminal trophic syndrome: a successful treatment with transcutaneous electrical stimulation. Br J Dermatol. 1983 May;108(5):601–604. [PubMed]
  • Abyholm FE, Eskeland G. Defect of the ala nasi following trigeminal denervation. Case report. Scand J Plast Reconstr Surg. 1977;11(1):87–90. [PubMed]
  • McLean NR, Watson AC. Reconstruction of a defect of the ala nasi following trigeminal anaesthesia with an innervated forehead flap. Br J Plast Surg. 1982 Apr;35(2):201–203. [PubMed]
  • Miglets AW. Factitial dermatitis following trigeminal denervation. Report of a case. Arch Otolaryngol. 1968 Aug;88(2):196–199. [PubMed]

Articles from Skull Base Surgery are provided here courtesy of Thieme Medical Publishers