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Skull base surgery. 1997; 7(3): 151–158.
PMCID: PMC1656637

Primary Neuroendocrine (Merkel Cell) Carcinoma of the Anterior Skull Base

Abstract

A case of a primary neuroendocrine (Merkel cell) carcinoma arising in the anterior skull base involving the dura, both frontal lobes, and the paranasal sinuses is presented. The tumor was completely removed by an enlarged bifrontal transbasal approach. The neuropathological, immunohistological, and electron microscopical investigation revealed all characteristics of a Merkel cell carcinoma, normally presenting as a skin carcinoma of the head and neck. The history, treatment, neuropathology, and possible explanation for this rare manifestation are discussed.

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Selected References

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  • Warner TF, Uno H, Hafez GR, Burgess J, Bolles C, Lloyd RV, Oka M. Merkel cells and Merkel cell tumors. Ultrastructure, immunocytochemistry and review of the literature. Cancer. 1983 Jul 15;52(2):238–245. [PubMed]
  • Wick MR, Goellner JR, Scheithauer BW, Thomas JR, 3rd, Sanchez NP, Schroeter AL. Primary neuroendocrine carcinomas of the skin (Merkel cell tumors). A clinical, histologic, and ultrastructural study of thirteen cases. Am J Clin Pathol. 1983 Jan;79(1):6–13. [PubMed]
  • Wilson BS, Lloyd RV. Detection of chromogranin in neuroendocrine cells with a monoclonal antibody. Am J Pathol. 1984 Jun;115(3):458–468. [PubMed]
  • Mercer D, Brander P, Liddell K. Merkel cell carcinoma: the clinical course. Ann Plast Surg. 1990 Aug;25(2):136–141. [PubMed]
  • Toker C. Trabecular carcinoma of the skin. Arch Dermatol. 1972 Jan;105(1):107–110. [PubMed]
  • De Wolff-Peeters C, Marien K, Mebis J, Desmet V. A cutaneous APUDoma or Merkel cell tumor? A morphologically recognizable tumor with a biological and histological malignant aspect in contrast with its clinical behavior. Cancer. 1980 Oct 15;46(8):1810–1816. [PubMed]
  • Frigerio B, Capella C, Eusebi V, Tenti P, Azzopardi JG. Merkel cell carcinoma of the skin: the structure and origin of normal Merkel cells. Histopathology. 1983 Mar;7(2):229–249. [PubMed]
  • Pilotti S, Rilke F, Lombardi L. Neuroendocrine (Merkel cell) carcinoma of the skin. Am J Surg Pathol. 1982 Apr;6(3):243–254. [PubMed]
  • Sibley RK, Dehner LP, Rosai J. Primary neuroendocrine (Merkel cell?) carcinoma of the skin. I. A clinicopathologic and ultrastructural study of 43 cases. Am J Surg Pathol. 1985 Feb;9(2):95–108. [PubMed]
  • Sidhu GS, Feiner H, Flotte TJ, Mullins JD, Schaefler K, Schultenover SJ. Merkel cell neoplasms. Histology, electron microscopy, biology, and histogenesis. Am J Dermatopathol. 1980 Summer;2(2):101–119. [PubMed]
  • Tang CK, Toker C. Trabecular carcinoma of the skin: further clinicopathologic and ultrastructural study. Mt Sinai J Med. 1979 Sep-Oct;46(5):516–523. [PubMed]
  • Hashimoto K. The ultrastructure of the skin of human embryos. X. Merkel tactile cells in the finger and nail. J Anat. 1972 Jan;111(Pt 1):99–120. [PubMed]
  • Silva EG, Ordóez NG, Lechago J. Immunohistochemical studies in endocrine carcinoma of the skin. Am J Clin Pathol. 1984 May;81(5):558–562. [PubMed]
  • Hashimoto K. Fine structure of Merkel cell in human oral mucosa. J Invest Dermatol. 1972 Jun;58(6):381–387. [PubMed]
  • Winkelmann RK, Breathnach AS. The Merkel cell. J Invest Dermatol. 1973 Jan;60(1):2–15. [PubMed]
  • Manome Y, Yamaoka R, Yuhki K, Hano H, Kitajima T, Ikeuchi S. [Intracranial invasion of neuroendocrine carcinoma: a case report]. No Shinkei Geka. 1990 May;18(5):483–487. [PubMed]
  • Mir R, Sciubba JJ, Bhuiya TA, Blomquist K, Zelig D, Friedman E. Merkel cell carcinoma arising in the oral mucosa. Oral Surg Oral Med Oral Pathol. 1988 Jan;65(1):71–75. [PubMed]
  • Reychler H, Bourlond A. Tumeur à cellules de Merkel de la lèvre supérieure. Rev Stomatol Chir Maxillofac. 1986;87(4):242–246. [PubMed]
  • Wojak JC, Murali R. Primary neuroendocrine (Merkel cell) carcinoma presenting in the calvarium: case report. Neurosurgery. 1990 Jan;26(1):137–139. [PubMed]
  • English KB. The ultrastructure of cutaneous type I mechanoreceptors (Haarscheiben) in cats following denervation. J Comp Neurol. 1977 Mar 1;172(1):137–163. [PubMed]
  • Heenan PJ, Cole JM, Spagnolo DV. Primary cutaneous neuroendocrine carcinoma (Merkel cell tumor). An adnexal epithelial neoplasm. Am J Dermatopathol. 1990 Feb;12(1):7–16. [PubMed]
  • Kroll MH, Toker C. Trabecular carcinoma of the skin: further clinicopathologic and morphologic study. Arch Pathol Lab Med. 1982 Aug;106(8):404–408. [PubMed]
  • Schenk P, Konrad K. Merkel cell carcinoma of the head and neck associated with Bowen's disease. Eur Arch Otorhinolaryngol. 1991;248(8):436–441. [PubMed]
  • Mayer TC. The migratory pathway of neural crest cells into the skin of mouse embryos. Dev Biol. 1973 Sep;34(1):39–46. [PubMed]
  • Raaf JH, Urmacher C, Knapper WK, Shiu MH, Cheng EW. Trabecular (Merkel cell) carcinoma of the skin. Treatment of primary, recurrent, and metastatic disease. Cancer. 1986 Jan 1;57(1):178–182. [PubMed]
  • Meland NB, Jackson IT. Merkel cell tumor: diagnosis, prognosis, and management. Plast Reconstr Surg. 1986 Apr;77(4):632–638. [PubMed]
  • Yiengpruksawan A, Coit DG, Thaler HT, Urmacher C, Knapper WK. Merkel cell carcinoma. Prognosis and management. Arch Surg. 1991 Dec;126(12):1514–1519. [PubMed]
  • Feun LG, Savaraj N, Legha SS, Silva EG, Benjamin RS, Burgess MA. Chemotherapy for metastatic Merkel cell carcinoma. Review of the M.D. Anderson Hospital's experience. Cancer. 1988 Aug 15;62(4):683–685. [PubMed]
  • Wynne CJ, Kearsley JH. Merkel cell tumor. A chemosensitive skin cancer. Cancer. 1988 Jul 1;62(1):28–31. [PubMed]

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