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Skull base surgery. 1997 January; 7(1): 39–41.
PMCID: PMC1656613

Anterior Skull Base Surgery for Secondary Malignancies in Retinoblastoma Survivors

Report of Two Cases


With the improved survival rate of patients with retinoblastoma, the incidence of second malignancies has become substantial. We had two retinoblastoma survivors with secondary malignancies in the naso-ethmoidal complex, one a 21-year-old man with anaplastic carcinoma and the other a 16-year-old girl with malignant fibrous histiocytoma. They underwent repeated craniofacial surgery. Secondary malignancies arising at the nose and ethmoidal cells often invade the anterior skull base. The introduction of skull base surgery has provided wider surgical margins and increased the resultant likelihood of cure. Both patients have so far shown no evidence of recurrence.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Friend SH, Dryja TP, Weinberg RA. Oncogenes and tumor-suppressing genes. N Engl J Med. 1988 Mar 10;318(10):618–622. [PubMed]
  • deFries HO, Deeb ZE, Hudkins CP. A transfacial approach to the nasal-paranasal cavities and anterior skull base. Arch Otolaryngol Head Neck Surg. 1988 Jul;114(7):766–769. [PubMed]
  • Schwarz MB, Burgess LP, Fee WE, Jr, Donaldson SS. Postirradiation sarcoma in retinoblastoma. Induction or predisposition? Arch Otolaryngol Head Neck Surg. 1988 Jun;114(6):640–644. [PubMed]
  • Smith LM, Donaldson SS, Egbert PR, Link MP, Bagshaw MA. Aggressive management of second primary tumors in survivors of hereditary retinoblastoma. Int J Radiat Oncol Biol Phys. 1989 Sep;17(3):499–505. [PubMed]

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