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Surgical reconstruction of the skull base and cranium adjacent to open paranasal sinuses with alloplastic materials is problematic secondary to an increased risk of implant infection in these locations. The authors report their initial experience with the use of a porous polyethylene implant for closure of defects in these locations in 20 patients, in 14 of these with the implant placed in direct contact with the mastoid or paranasal simuses. The implant is flexible, which facilitates surgical reconstruction of the cranial base, and porous in nature, which enhances soft tissue and bone ingrowth in decrease the risk of infection. The implant is radiolucent on plain roentgenograms and CT, and produces no imaging artifact on MRI. The implant was utilized for a variety of skull base of cranium adjacent to sinus reconstructive applications with no infectious complications, with a follow-up period ranging from 8 to 50 months. This preliminary experience suggests that the alloplast may be a useful adjunct in skull base reconstruction, and further evaluation of its use in this application is warranted.