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Skull base surgery. 1995 October; 5(4): 269–272.
PMCID: PMC1656535

Sinonasal Undifferentiated Carcinoma

Current Trends in Treatment


Sinonasal undifferentiated carcinoma (SNUC) is a rare and highly aggressive neoplasm of the paranasal sinuses, which has recently been characterized as a distinct pathologic entity. The prognosis for patients with SNUC is poor. Early case reports describe patients with lesions that were clinically advanced at initial presentation and surgically unresectable. Survival was reported in months after treatment with chemotherapy and radiation. As more experience was gained with treatment of SNUC, it was found that aggressive, combined surgical therapy of lesions previously considered unresectable has shown increased survival. We report a case of a 38-year-old man with SNUC originating in the posterior ethmoid, extending into the anterior cranial fossa and orbit, who was treated with preoperative hyperfractionated radiation therapy, chemotherapy, and craniofacial resection.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Frierson HF, Jr, Mills SE, Fechner RE, Taxy JB, Levine PA. Sinonasal undifferentiated carcinoma. An aggressive neoplasm derived from schneiderian epithelium and distinct from olfactory neuroblastoma. Am J Surg Pathol. 1986 Nov;10(11):771–779. [PubMed]
  • Levine PA, Frierson HF, Jr, Stewart FM, Mills SE, Fechner RE, Cantrell RW. Sinonasal undifferentiated carcinoma: a distinctive and highly aggressive neoplasm. Laryngoscope. 1987 Aug;97(8 Pt 1):905–908. [PubMed]
  • Weiss R, Myssiorek D, Kahn L, Patel M. Laryngeal squamous cell carcinoma metastatic to the pituitary gland: a case study. Otolaryngol Head Neck Surg. 1994 Dec;111(6):816–819. [PubMed]
  • Gallo O, Graziani P, Fini-Storchi O. Undifferentiated carcinoma of the nose and paranasal sinuses. An immunohistochemical and clinical study. Ear Nose Throat J. 1993 Sep;72(9):588–595. [PubMed]
  • Deutsch BD, Levine PA, Stewart FM, Frierson HF, Jr, Cantrell RW. Sinonasal undifferentiated carcinoma: a ray of hope. Otolaryngol Head Neck Surg. 1993 Jun;108(6):697–700. [PubMed]
  • McCaffrey TV, Olsen KD, Yohanan JM, Lewis JE, Ebersold MJ, Piepgras DG. Factors affecting survival of patients with tumors of the anterior skull base. Laryngoscope. 1994 Aug;104(8 Pt 1):940–945. [PubMed]
  • Shah JP, Sundaresan N, Galicich J, Strong EW. Craniofacial resections for tumors involving the base of the skull. Am J Surg. 1987 Oct;154(4):352–358. [PubMed]
  • Shah JP, Kraus DH, Arbit E, Galicich JH, Strong EW. Craniofacial resection for tumors involving the anterior skull base. Otolaryngol Head Neck Surg. 1992 Apr;106(4):387–393. [PubMed]
  • Kraus DH, Sterman BM, Levine HL, Wood BG, Tucker HM, Lavertu P. Factors influencing survival in ethmoid sinus cancer. Arch Otolaryngol Head Neck Surg. 1992 Apr;118(4):367–372. [PubMed]
  • Van Tuyl R, Gussack GS. Prognostic factors in craniofacial surgery. Laryngoscope. 1991 Mar;101(3):240–244. [PubMed]
  • Janecka IP, Sen C, Sekhar L, Curtin H. Treatment of paranasal sinus cancer with cranial base surgery: results. Laryngoscope. 1994 May;104(5 Pt 1):553–555. [PubMed]
  • Eibling DE, Janecka IP, Snyderman CH, Cass SP. Meta-analysis of outcome in anterior skull base resection for squamous cell and undifferentiated carcinoma. Skull Base Surg. 1993;3(3):123–129. [PMC free article] [PubMed]
  • Levine PA, Debo RF, Meredith SD, Jane JA, Constable WC, Cantrell RW. Craniofacial resection at the University of Virginia (1976-1992): survival analysis. Head Neck. 1994 Nov-Dec;16(6):574–577. [PubMed]
  • Catalano PJ, Hecht CS, Biller HF, Lawson W, Post KD, Sachdev V, Sen C, Urken ML. Craniofacial resection. An analysis of 73 cases. Arch Otolaryngol Head Neck Surg. 1994 Nov;120(11):1203–1208. [PubMed]
  • Kraus DH, Shah JP, Arbit E, Galicich JH, Strong EW. Complications of craniofacial resection for tumors involving the anterior skull base. Head Neck. 1994 Jul-Aug;16(4):307–312. [PubMed]
  • Kadish S, Goodman M, Wang CC. Olfactory neuroblastoma. A clinical analysis of 17 cases. Cancer. 1976 Mar;37(3):1571–1576. [PubMed]

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