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Skull base surgery. 1992 January; 2(1): 1–5.
PMCID: PMC1656391

Management of Metastatic Glomus Jugulare Tumors

Abstract

Metastatic glomus jugulare tumors (jugular paragangliomas) are very uncommon: consequently, no single report has been able to accurately describe their biologic or clinical behavior, and there are no established guidelines on caring for patients with these tumors. Identification of metastatic paraganglioma can be difficult because these tumors are known to occur synchronously, many other tumor types appear histologically similar to paragangliomas, and histologically the metastasis may not resemble the primary tumor. Immunohistochemistry, using neuroendocrine markers, and electron microscopy are the two most useful techniques available to identify definitely paragangliomas. A few studies have shown differences in the immunohistochemical staining patterns between benign and metastatic paragangliomas. We reviewed the literature and include two additional cases of metastatic glomus jugulare tumors in this article. We discuss the clinical management of these patients, the importance and usefulness of immunohistochemistry in characterizing these tumors, and their clinical outcomes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Spector GJ, Ciralsky R, Maisel RH, Ogura JH. IV. Multiple glomus tumors in the head and neck. Laryngoscope. 1975 Jun;85(6):1066–1075. [PubMed]
  • Schwaber MK, Glasscock ME, Nissen AJ, Jackson CG, Smith PG. Diagnosis and management of catecholamine secreting glomus tumors. Laryngoscope. 1984 Aug;94(8):1008–1015. [PubMed]
  • Johnson TL, Zarbo RJ, Lloyd RV, Crissman JD. Paragangliomas of the head and neck: immunohistochemical neuroendocrine and intermediate filament typing. Mod Pathol. 1988 May;1(3):216–223. [PubMed]
  • Bhansali SA, Bojrab DI, Zarbo RJ. Malignant paragangliomas of the head and neck: clinical and immunohistochemical characterization. Otolaryngol Head Neck Surg. 1991 Jan;104(1):132–132. [PubMed]
  • Davis JM, Davis KR, Hesselink JR, Greene R. Malignant glomus jugulare tumor: a case with two unusual radiographic features. J Comput Assist Tomogr. 1980 Jun;4(3):415–417. [PubMed]
  • El Fiky FM, Paparella MM. A metastatic glomus jugulare tumor. A temporal bone report. Am J Otol. 1984 Jan;5(3):197–200. [PubMed]
  • Sakakura T, Makita Y, Nabeshima S, Tei T, Nagayasu S, Miyamoto Y. [Chemodectoma of the glomus jugulare with multiple metastases. Case report]. Neurol Med Chir (Tokyo) 1986 Sep;26(9):701–705. [PubMed]
  • Takahashi H, Nakashima S, Kumanishi T, Ikuta F. Paragangliomas of the craniocervical region. An immunohistochemical study on tyrosine hydroxylase. Acta Neuropathol. 1987;73(3):227–232. [PubMed]
  • Tu H, Bottomley RH. Malignant chemodectoma presenting as a miliary pulmonary infiltrate. Cancer. 1974 Jan;33(1):244–249. [PubMed]
  • Baulieu JL, Guilloteau D, Baulieu F, Le Floch O, Chambon C, Pourcelot L, Besnard JC. Therapeutic effectiveness of iodine-131 MIBG metastases of a nonsecreting paraganglioma. J Nucl Med. 1988 Dec;29(12):2008–2013. [PubMed]
  • Glasscock ME, 3rd, Harris PF, Newsome G. Glomus tumors: diagnosis and treatment. Laryngoscope. 1974 Nov;84(11):2006–2032. [PubMed]

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