Search tips
Search criteria 


Logo of skullbasesurgInstructions for AuthorsSubscribe to Skull BaseAbout Skull BaseEditorial BoardThieme Medical PublishingSkull Base An Interdisciplinary Approach ...
Skull base surgery. 1992 October; 2(4): 195–198.
PMCID: PMC1656377


A Flow Cytometric Evaluation of 31 Cases


Angiofibromas are histologically benign but locally aggressive tumors that often extend beyond the nasopharynx to involve contiguous structures. In addition, attempts to remove the tumors surgically are often frustrated by local recurrences. We studied 31 angiofibromas by flow cytometry to determine if tumor ploidy could be used to identify those tumors that might behave more aggressively. The patients, all males between 5 and 23 years of age, were divided into two groups. The 21 patients with tumors confined to the nasopharynx or paranasal sinuses were regarded as having local disease, the ten with tumors involving the infratemporal fossa, orbit, cheek, or intracranial structures were regarded as having extensive disease. Of the ten with extensive disease, six bad intracranial involvement. All patients were treated with surgery and only one received postoperative irradiation. Follow-up was available in 24, eight of which developed local recurrences (33%). All tumors, including recurrences and those with intracranial extension, were found to be diploid. We therefore conclude that tumor ploidy cannot be used to predict the clinical course of angiofibromas.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1006K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Images in this article

Click on the image to see a larger version.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Sessions RB, Bryan RN, Naclerio RM, Alford BR. Radiographic staging of juvenile angiofibroma. Head Neck Surg. 1981 Mar-Apr;3(4):279–283. [PubMed]
  • Harrison DF. The natural history, pathogenesis, and treatment of juvenile angiofibroma. Personal experience with 44 patients. Arch Otolaryngol Head Neck Surg. 1987 Sep;113(9):936–942. [PubMed]
  • Witt TR, Shah JP, Sternberg SS. Juvenile nasopharyngeal angiofibroma. A 30 year clinical review. Am J Surg. 1983 Oct;146(4):521–525. [PubMed]
  • Chandler JR, Goulding R, Moskowitz L, Quencer RM. Nasopharyngeal angiofibromas: staging and management. Ann Otol Rhinol Laryngol. 1984 Jul-Aug;93(4 Pt 1):322–329. [PubMed]
  • Bremer JW, Neel HB, 3rd, DeSanto LW, Jones GC. Angiofibroma: treatment trends in 150 patients during 40 years. Laryngoscope. 1986 Dec;96(12):1321–1329. [PubMed]
  • Antonelli AR, Cappiello J, Di Lorenzo D, Donajo CA, Nicolai P, Orlandini A. Diagnosis, staging, and treatment of juvenile nasopharyngeal angiofibroma (JNA). Laryngoscope. 1987 Nov;97(11):1319–1325. [PubMed]
  • Spector JG. Management of juvenile angiofibromata. Laryngoscope. 1988 Sep;98(9):1016–1026. [PubMed]
  • Hedley DW, Friedlander ML, Taylor IW, Rugg CA, Musgrove EA. Method for analysis of cellular DNA content of paraffin-embedded pathological material using flow cytometry. J Histochem Cytochem. 1983 Nov;31(11):1333–1335. [PubMed]
  • Vindeløv LL, Christensen IJ, Nissen NI. A detergent-trypsin method for the preparation of nuclei for flow cytometric DNA analysis. Cytometry. 1983 Mar;3(5):323–327. [PubMed]
  • Seckinger D, Sugarbaker E, Frankfurt O. DNA content in human cancer. Application in pathology and clinical medicine. Arch Pathol Lab Med. 1989 Jun;113(6):619–626. [PubMed]
  • Merkel DE, McGuire WL. Ploidy, proliferative activity and prognosis. DNA flow cytometry of solid tumors. Cancer. 1990 Mar 1;65(5):1194–1205. [PubMed]
  • Stell PM. Ploidy in head and neck cancer: a review and meta-analysis. Clin Otolaryngol Allied Sci. 1991 Oct;16(5):510–516. [PubMed]
  • Barnes L, Taylor SR. Carotid body paragangliomas. A clinicopathologic and DNA analysis of 13 tumors. Arch Otolaryngol Head Neck Surg. 1990 Apr;116(4):447–453. [PubMed]
  • Barnes L, Taylor SR. Vagal paragangliomas: a clinical, pathological, and DNA assessment. Clin Otolaryngol Allied Sci. 1991 Aug;16(4):376–382. [PubMed]

Articles from Skull Base Surgery are provided here courtesy of Thieme Medical Publishers