Search tips
Search criteria 


Logo of skullbasesurgInstructions for AuthorsSubscribe to Skull BaseAbout Skull BaseEditorial BoardThieme Medical PublishingSkull Base An Interdisciplinary Approach ...
Skull base surgery. 1992 April; 2(2): 112–117.
PMCID: PMC1656353

Mesenchymal Tumors of the Skull Base with Particular Reference to Surgical Management and Outcome


Nine patients with mesenchymal tumors of the skull base have undergone radical tumor excision by the use of the Infratemporal fossa approach. Three cases of chondrosarcoma, two of leiomyosarcoma, and one case each of synovial sarcoma, chondroid chordoma, myxoma, and fibromatosis were managed. In the mean postoperative review time of 6.6 years (range 1.7 to 13) there are no clinical or radiologic signs of recurrence at the primary site in any patient, although two have developed distant metastases. The purpose of this article is to demonstrate that, with aggressive and preferably early surgical management using this type of access to the skull base, complete removal of these tumors can be undertaken, and it is now possible to achieve permanent ablation of this type of pathologic condition at the skull base.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.8M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Images in this article

Click on the image to see a larger version.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Fisch U, Fagan P, Valavanis A. The infratemporal fossa approach for the lateral skull base. Otolaryngol Clin North Am. 1984 Aug;17(3):513–552. [PubMed]
  • Andrews JC, Valavanis A, Fisch U. Management of the internal carotid artery in surgery of the skull base. Laryngoscope. 1989 Dec;99(12):1224–1229. [PubMed]
  • Heffelfinger MJ, Dahlin DC, MacCarty CS, Beabout JW. Chordomas and cartilaginous tumors at the skull base. Cancer. 1973 Aug;32(2):410–420. [PubMed]
  • Kahn HJ, Marks A, Thom H, Baumal R. Role of antibody to S100 protein in diagnostic pathology. Am J Clin Pathol. 1983 Mar;79(3):341–347. [PubMed]
  • Wolff M, Silva F, Kaye G. Pulmonary metastases (with admixed epithelial elements) from smooth muscle neoplasms. Report of nine cases, including three males. Am J Surg Pathol. 1979 Aug;3(4):325–342. [PubMed]
  • House WF, Hitselberger WE, Horn KL. The middle fossa transpetrous approach to the anterior-superior cerebellopontine angle. Am J Otol. 1986 Jan;7(1):1–4. [PubMed]
  • House WF, Hitselberger WE. The transcochlear approach to the skull base. Arch Otolaryngol. 1976 Jun;102(6):334–342. [PubMed]
  • Al-Mefty O, Fox JL, Rifai A, Smith RR. A combined infratemporal and posterior fossa approach for the removal of giant glomus tumors and chondrosarcomas. Surg Neurol. 1987 Dec;28(6):423–431. [PubMed]
  • Sekhar LN, Schramm VL, Jr, Jones NF. Subtemporal-preauricular infratemporal fossa approach to large lateral and posterior cranial base neoplasms. J Neurosurg. 1987 Oct;67(4):488–499. [PubMed]
  • Gacek RR. Diagnosis and management of primary tumors of the petrous apex. Ann Otol Rhinol Laryngol. 1975 Jan-Feb;84(1 Pt 2 Suppl 18):1–20. [PubMed]
  • Suit HD, Goitein M, Munzenrider J, Verhey L, Davis KR, Koehler A, Linggood R, Ojemann RG. Definitive radiation therapy for chordoma and chondrosarcoma of base of skull and cervical spine. J Neurosurg. 1982 Mar;56(3):377–385. [PubMed]

Articles from Skull Base Surgery are provided here courtesy of Thieme Medical Publishers