PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of skullbaseInstructions for AuthorsSubscribe to Skull BaseAbout Skull BaseEditorial BoardThieme Medical PublishingSkull Base An Interdisciplinary Approach ...
 
Skull Base. 2002 February; 12(1): 9–17.
PMCID: PMC1654772

Recurrent Giant Cell Reparative Granuloma of the Skull Base and the Paranasal Sinuses Presenting with Acute One-Sided Blindness

Abstract

The etiology, pathogenesis, histopathologic diagnosis, prognosis, and treatment of giant cell reparative granulomas of the skull are controversial. We report a 14-year-old girl with an advanced recurrent giant cell reparative granuloma of the skull base and paranasal sinuses whose only clinical manifestation was a loss of vision. After undergoing endovascular catheter embolization, the patient underwent repeated surgical resections of the mass via a combined frontobasal and modified infratemporal approach followed by radiation therapy. Histopathologic examination confirmed the diagnosis of giant cell reparative granuloma. A traumatic event in the patient's history—a fossa canina abscess followed by tooth extraction 14 months before admission—supports the theory of a reactive reparative process as a pathogenetic mechanism for this disease. Histopathologic criteria and clinical aggressiveness must be considered to achieve adequate treatment of giant cell lesions of the skull.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (2.5M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Schajowicz F, Sissons HA, Sobin LH. The World Health Organization's histologic classification of bone tumors. A commentary on the second edition. Cancer. 1995 Mar 1;75(5):1208–1214. [PubMed]
  • Tallan EM, Olsen KD, McCaffrey TV, Unni KK, Lund BA. Advanced giant cell granuloma: a twenty-year study. Otolaryngol Head Neck Surg. 1994 Apr;110(4):413–418. [PubMed]
  • JAFFE HL. Giant-cell reparative granuloma, traumatic bone cyst, and fibrous (fibro-oseous) dysplasia of the jawbones. Oral Surg Oral Med Oral Pathol. 1953 Jan;6(1):159–175. [PubMed]
  • Rhea JT, Weber AL. Giant-cell granuloma of the sinuses. Radiology. 1983 Apr;147(1):135–137. [PubMed]
  • Katz A, Hirschl S. Giant cell reparative granuloma in the temporal bone. Arch Otolaryngol. 1974 Nov;100(5):380–382. [PubMed]
  • Lewis ML, Weber AL, McKenna MJ. Reparative cell granuloma of the temporal bone. Ann Otol Rhinol Laryngol. 1994 Oct;103(10):826–828. [PubMed]
  • Ung F, Li KK, Keith DA, McKenna MJ. Giant cell reparative granuloma of the temporal bone: case report and review of the literature. Otolaryngol Head Neck Surg. 1998 Apr;118(4):525–529. [PubMed]
  • Friedberg SA, Eisenstein R, Wallner LJ. Giant cell lesions involving the nasal accessory sinuses. Laryngoscope. 1969 May;79(5):763–776. [PubMed]
  • Wiatrak BJ, Gluckman JL, Fabian RL, Wesseler TA. Giant cell reparative granuloma of the ethmoid sinus. Otolaryngol Head Neck Surg. 1987 Nov;97(5):504–509. [PubMed]
  • Ciappetta P, Salvati M, Bernardi C, Raco A, Di Lorenzo N. Giant cell reparative granuloma of the skull base mimicking an intracranial tumor. Case report and review of the literature. Surg Neurol. 1990 Jan;33(1):52–56. [PubMed]
  • Hoopes PC, Anderson RL, Blodi FC. Giant cell (reparative) granuloma of the orbit. Ophthalmology. 1981 Dec;88(12):1361–1366. [PubMed]
  • Hirschl S, Katz A. Giant cell reparative granuloma outside the jaw bone. Diagnostic criteria and review of the literature with the first case described in the temporal bone. Hum Pathol. 1974 Mar;5(2):171–181. [PubMed]
  • Lorenzo JC, Dorfman HD. Giant-cell reparative granuloma of short tubular bones of the hands and feet. Am J Surg Pathol. 1980 Dec;4(6):551–563. [PubMed]
  • Wold LE, Dobyns JH, Swee RG, Dahlin DC. Giant cell reaction (giant cell reparative granuloma) of the small bones of the hands and feet. Am J Surg Pathol. 1986 Jul;10(7):491–496. [PubMed]
  • Schulz A, Maerker R, Delling G. Das zentrale Riesenzellgranulom. Histochemische und ultrastrukturelle Untersuchungen zur Funktion und Aktivität der Riesenzellen. Virchows Arch A Pathol Anat Histol. 1976 Aug 23;371(2):161–170. [PubMed]
  • Colclasure JB, Shea MC, Jr, Graham SS. Giant cell lesions of the temporal bone. Am J Otol. 1981 Jan;2(3):188–192. [PubMed]
  • Chuong R, Kaban LB, Kozakewich H, Perez-Atayde A. Central giant cell lesions of the jaws: a clinicopathologic study. J Oral Maxillofac Surg. 1986 Sep;44(9):708–713. [PubMed]
  • Weber AL, Hug EB, Muenter MW, Curtin HD. Giant-cell tumors of the sphenoid bone in four children: radiological, clinical, and pathological findings. Skull Base Surg. 1997;7(4):163–173. [PMC free article] [PubMed]
  • Auclair PL, Cuenin P, Kratochvil FJ, Slater LJ, Ellis GL. A clinical and histomorphologic comparison of the central giant cell granuloma and the giant cell tumor. Oral Surg Oral Med Oral Pathol. 1988 Aug;66(2):197–208. [PubMed]
  • Eisenbud L, Stern M, Rothberg M, Sachs SA. Central giant cell granuloma of the jaws: experiences in the management of thirty-seven cases. J Oral Maxillofac Surg. 1988 May;46(5):376–384. [PubMed]
  • Saleh EA, Taibah AK, Naguib M, Aristegui M, Vassallo G, Landolfi M, Sanna M. Giant cell tumor of the lateral skull base: a case report. Otolaryngol Head Neck Surg. 1994 Sep;111(3 Pt 1):314–318. [PubMed]

Articles from Skull Base are provided here courtesy of Thieme Medical Publishers