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Antimicrob Agents Chemother. 1996 October; 40(10): 2423–2425.
PMCID: PMC163547

Prenatal and postpartum pharmacokinetics of stavudine (2',3'-didehydro-3'-deoxythymidine) and didanosine (dideoxyinosine) in pigtailed macaques (Macaca nemestrina).


Stavudine (5 mg/kg of body weight; n = 7) or didanosine (3.2 mg/kg; n = 4) was administered as an intravenous bolus to pregnant pigtailed macaques (Macaca nemestrina) near term and 4 to 5 weeks postpartum. No significant differences were found between the prenatal and postpartum total plasma drug clearance, steady-state volume of distribution, terminal plasma drug half-life, mean body residence time, or recovery of unchanged drug in urine. These data indicate that pregnancy does not affect the pharmacokinetics of stavudine or didanosine in M. nemestrina.

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Selected References

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  • Browne MJ, Mayer KH, Chafee SB, Dudley MN, Posner MR, Steinberg SM, Graham KK, Geletko SM, Zinner SH, Denman SL, et al. 2',3'-didehydro-3'-deoxythymidine (d4T) in patients with AIDS or AIDS-related complex: a phase I trial. J Infect Dis. 1993 Jan;167(1):21–29. [PubMed]
  • Connor EM, Sperling RS, Gelber R, Kiselev P, Scott G, O'Sullivan MJ, VanDyke R, Bey M, Shearer W, Jacobson RL, et al. Reduction of maternal-infant transmission of human immunodeficiency virus type 1 with zidovudine treatment. Pediatric AIDS Clinical Trials Group Protocol 076 Study Group. N Engl J Med. 1994 Nov 3;331(18):1173–1180. [PubMed]
  • Cretton EM, Zhou Z, Kidd LB, McClure HM, Kaul S, Hitchcock MJ, Sommadossi JP. In vitro and in vivo disposition and metabolism of 3'-deoxy-2',3'-didehydrothymidine. Antimicrob Agents Chemother. 1993 Sep;37(9):1816–1825. [PMC free article] [PubMed]
  • Du DL, Volpe DA, Grieshaber CK, Murphy MJ., Jr In vitro toxicity of 3'-azido-3'-deoxythymidine, carbovir and 2',3'-didehydro-2',3'-dideoxythymidine to human and murine haematopoietic progenitor cells. Br J Haematol. 1992 Apr;80(4):437–445. [PubMed]
  • Dudley MN, Graham KK, Kaul S, Geletko S, Dunkle L, Browne M, Mayer K. Pharmacokinetics of stavudine in patients with AIDS or AIDS-related complex. J Infect Dis. 1992 Sep;166(3):480–485. [PubMed]
  • Hartman NR, Yarchoan R, Pluda JM, Thomas RV, Marczyk KS, Broder S, Johns DG. Pharmacokinetics of 2',3'-dideoxyadenosine and 2',3'-dideoxyinosine in patients with severe human immunodeficiency virus infection. Clin Pharmacol Ther. 1990 May;47(5):647–654. [PubMed]
  • Kaul S, Dandekar KA. Pharmacokinetics of the anti-human immunodeficiency virus nucleoside analog stavudine in cynomolgus monkeys. Antimicrob Agents Chemother. 1993 May;37(5):1160–1162. [PMC free article] [PubMed]
  • Knupp CA, Shyu WC, Dolin R, Valentine FT, McLaren C, Martin RR, Pittman KA, Barbhaiya RH. Pharmacokinetics of didanosine in patients with acquired immunodeficiency syndrome or acquired immunodeficiency syndrome-related complex. Clin Pharmacol Ther. 1991 May;49(5):523–535. [PubMed]
  • Krauer B, Krauer F, Hytten FE. Drug disposition and pharmacokinetics in the maternal-placental-fetal unit. Pharmacol Ther. 1980;10(2):301–328. [PubMed]
  • Lambert JS. Maternal-fetal transmission of HIV-1 infection. Pediatr Ann. 1993 Jul;22(7):413–416. [PubMed]
  • Lopez-Anaya A, Unadkat JD, Schumann LA, Smith AL. Pharmacokinetics of zidovudine (azidothymidine). III. Effect of pregnancy. J Acquir Immune Defic Syndr. 1991;4(1):64–68. [PubMed]
  • Mansuri MM, Hitchcock MJ, Buroker RA, Bregman CL, Ghazzouli I, Desiderio JV, Starrett JE, Sterzycki RZ, Martin JC. Comparison of in vitro biological properties and mouse toxicities of three thymidine analogs active against human immunodeficiency virus. Antimicrob Agents Chemother. 1990 Apr;34(4):637–641. [PMC free article] [PubMed]
  • Merigan TC. Treatment of AIDS with combinations of antiretroviral agents. Am J Med. 1991 Apr 10;90(4A):8S–17S. [PubMed]
  • Morton WR, Knitter GH, Smith PM, Susor TG, Schmitt K. Alternatives to chronic restraint of nonhuman primates. J Am Vet Med Assoc. 1987 Nov 15;191(10):1282–1286. [PubMed]
  • Nöschel H, Peiker G, Voigt R, Meinhold P, Müller B, Schröder S, Bonow A. Research on pharmacokinetics during pregnancy. Arch Toxicol Suppl. 1980;4:380–384. [PubMed]
  • Ochs HD, Morton WR, Tsai CC, Thouless ME, Zhu Q, Kuller LD, Wu YP, Benveniste RE. Maternal-fetal transmission of SIV in macaques: disseminated adenovirus infection in an offspring with congenital SIV infection. J Med Primatol. 1991 Jun;20(4):193–200. [PubMed]
  • Odinecs A, Nosbisch C, Keller RD, Baughman WL, Unadkat JD. In vivo maternal-fetal pharmacokinetics of stavudine (2',3'-didehydro-3'-deoxythymidine) in pigtailed macaques (Macaca nemestrina). Antimicrob Agents Chemother. 1996 Jan;40(1):196–202. [PMC free article] [PubMed]
  • Pereira CM, Nosbisch C, Winter HR, Baughman WL, Unadkat JD. Transplacental pharmacokinetics of dideoxyinosine in pigtailed macaques. Antimicrob Agents Chemother. 1994 Apr;38(4):781–786. [PMC free article] [PubMed]
  • Ravasco RJ, Unadkat JD, Tsai CC, Nosbisch C. Pharmacokinetics of dideoxyinosine in pigtailed macaques (Macaca nemestrina) after intravenous and subcutaneous administration. J Acquir Immune Defic Syndr. 1992 Oct;5(10):1016–1018. [PubMed]
  • Rocci ML, Jr, Jusko WJ. LAGRAN program for area and moments in pharmacokinetic analysis. Comput Programs Biomed. 1983 Jun;16(3):203–216. [PubMed]
  • Russell JW, Whiterock VJ, Marrero D, Klunk LJ. Disposition in animals of a new anti-HIV agent: 2',3'-didehydro-3'-deoxythymidine. Drug Metab Dispos. 1990 Mar-Apr;18(2):153–157. [PubMed]
  • Schinazi RF, Boudinot FD, Doshi KJ, McClure HM. Pharmacokinetics of 3'-fluoro-3'-deoxythymidine and 3'-deoxy-2',3'-didehydrothymidine in rhesus monkeys. Antimicrob Agents Chemother. 1990 Jun;34(6):1214–1219. [PMC free article] [PubMed]

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