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Br Med J. 1974 March 9; 1(5905): 409–412.
PMCID: PMC1633257

Menopausal Flushing: Double-blind Trial of a Non-hormonal Medication


A multicentre, placebo-controlled, double-blind, cross-over study conducted in general practice on 100 patients has shown clonidine to have a statistically highly significant effect in controlling the number and the severity and duration of menopausal flushes. The relatively mild side effects and the absence of potentially harmful oestrogenic effects suggest that clonidine in the dose range 25 to 75 μg twice daily is a useful addition or alternative to the existing therapy for this common symptom of the menopause.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Clayden JR. Effect of clonidine on menopausal flushing. Lancet. 1972 Dec 23;2(7791):1361–1361. [PubMed]
  • HAZAN SJ, CONNEELY R. THE MENOPAUSE--FLUSH, FANTASY, AND DENIAL. West J Surg Obstet Gynecol. 1964 May-Jun;72:167–170. [PubMed]
  • Shafar J, Tallett ER, Knowlson PA. Evaluation of clonidine in prophylaxis of migraine. Double-blind trial and follow-up. Lancet. 1972 Feb 19;1(7747):403–407. [PubMed]
  • Williams CB, Lawrie JH, Baker PR, Forrest AP. Gastric acid production in jaundice. Lancet. 1968 Feb 24;1(7539):388–390. [PubMed]
  • Zaimis E, Hanington E. A possible pharmacological approach to migraine. Lancet. 1969 Aug 9;2(7615):298–300. [PubMed]

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