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Br Med J. 1969 October 4; 4(5674): 11–14.
PMCID: PMC1629614

Creatinine clearance in renal disease. A reappraisal

Abstract

To determine the validity of endogenous creatinine clearance as a measure of glomerular filtration rate in patients with renal disease 308 simultaneous determinations of inulin clearance and endogenous creatinine clearance were reviewed and analysed. The ratio of creatinine clearance/inulin clearance increased progressively with the decline in inulin clearance, while the finding of a normal endogenous creatinine clearance masked a definite but mild decrease of glomerular filtration rate in 42% of the patients and a moderate decrease of glomerular filtration rate in 23%. This indicates that with declining glomerular filtration rates the endogenous creatinine clearance progressively overestimates actual glomerular filtration rates. Hence a single determination of creatinine clearance can be misleading as a screening measurement of glomerular filtration rate.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • BERLYNE GM, VARLEY H, NILWARANGKUR S, HOERNI M. ENDOGENOUS-CREATININE CLEARANCE AND GLOMERULAR-FILTRATION RATE. Lancet. 1964 Oct 24;2(7365):874–876. [PubMed]
  • DOERING P, KOCH R, SCHROETER H, SCHWAB M. Die endogene Kreatininclearance beim Nierenkranken Menschen. Klin Wochenschr. 1953 Jun 1;31(21-22):489–496. [PubMed]
  • DOOLAN PD, ALPEN EL, THEIL GB. A clinical appraisal of the plasma concentration and endogenous clearance of creatinine. Am J Med. 1962 Jan;32:65–79. [PubMed]
  • EDWARDS KD, WHYTE HM. Plasma creatinine level and creatinine clearance as tests of renal function. Australas Ann Med. 1959 Aug;8:218–224. [PubMed]
  • EFFERSOE P. Relationship between endogenous 24-hour creatinine clearance and serum creatinine concentration in patients with chronic renal disease. Acta Med Scand. 1957 Feb 2;156(6):429–434. [PubMed]
  • MATTAR G, BARNETT HL, MCNAMARA H, LAUSON HD. Measurement of glomerular filtration rate in children with kidney disease. J Clin Invest. 1952 Oct;31(10):938–946. [PMC free article] [PubMed]
  • MILLER BF, LEAF A, MAMBY AR, MILLER Z. Validity of the endogenous creatinine clearance as a measure of glomerular filtration rate in the diseased human kidney. J Clin Invest. 1952 Mar;31(3):309–313. [PMC free article] [PubMed]
  • Miller BF, Winkler AW. THE RENAL EXCRETION OF ENDOGENOUS CREATININE IN MAN. COMPARISON WITH EXOGENOUS CREATININE AND INULIN. J Clin Invest. 1938 Jan;17(1):31–40. [PMC free article] [PubMed]
  • Rapoport A, Husdan H. Endogenous creatinine clearance and serum creatinine in the clinical assessment of kidney function. Can Med Assoc J. 1968 Jul 27;99(4):149–156. [PMC free article] [PubMed]
  • Shannon JA, Ranges HA. ON THE RENAL TUBULAR EXCRETION OF CREATININE IN NORMAL MAN. J Clin Invest. 1941 Mar;20(2):169–176. [PMC free article] [PubMed]
  • TOBIAS GJ, McLAUGHLIN RF, Jr, HOPPER J., Jr Endogenous creatinine clearance. A valuable clinical test of glomerular filtration and a prognostic guide in chronic renal disease. N Engl J Med. 1962 Feb 15;266:317–323. [PubMed]
  • VERE DW, WALDUCK A. ENDOGENOUS-CREATININE CLEARANCE AND GLOMERULAR FILTRATION-RATE. Lancet. 1964 Dec 12;2(7372):1299–1299. [PubMed]

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