PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of archdischArchives of Disease in ChildhoodVisit this articleSubmit a manuscriptReceive email alertsContact usBMJ
 
Arch Dis Child. 1982 June; 57(6): 438–442.
PMCID: PMC1627662

Stage II neuroblastoma. Adverse prognostic significance of lymph node involvement.

Abstract

Thirty-three children aged between 1 month and 16 years (median 1 year, 7 months), were treated for stage II neuroblastoma with surgery, radiotherapy, or chemotherapy, alone or in combination. After 3 years 70% were living, 6 children had died from the disease, and 4 had died as a result of treatment. Patient characteristics (age, gender) and tumour characteristics primary site, presence of lymph node involvement, catecholamine excretion, histology) were reviewed in an attempt to determine prognostic features. While age under 1 year at diagnosis was, as expected, favourable in this series, the most important prognostic variable was the presence or absence of regional lymph node involvement. No patient with uninvolved nodes died of neuroblastoma and the difference in the 3-year survival rate between these patients and those with positive nodes was statistically significant. Although this study of patients treated between 1970 and 1977 provided no clear evidence that either postoperative radiotherapy or contemporary chemotherapy was of benefit, our findings suggest that subclassification of stage II patients into 'node-positive' and 'node-negative' groups will help to define those who might benefit from improved adjuvant postsurgical treatment.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (698K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Evans AE, D'Angio GJ, Randolph J. A proposed staging for children with neuroblastoma. Children's cancer study group A. Cancer. 1971 Feb;27(2):374–378. [PubMed]
  • Jaffe N. Neuroblastoma: review of the literature and an examination of factors contributing to its enigmatic charcter. Cancer Treat Rev. 1976 Jun;3(2):61–82. [PubMed]
  • Wilson LM, Draper GJ. Neuroblastoma, its natural history and prognosis: a study of 487 cases. Br Med J. 1974 Aug 3;3(5926):301–307. [PMC free article] [PubMed]
  • Koop CE, Johnson DG. Neuroblastoma: an assessment of therapy in reference to staging. J Pediatr Surg. 1971 Oct;6(5):595–600. [PubMed]
  • Evans AE, Albo V, D'Angio GJ, Finklestein JZ, Leiken S, Santulli T, Weiner J, Hammond GD. Cyclophoshamide treatment of patients with localized and regional neuroblastoma: A randomized study. Cancer. 1976 Aug;38(2):655–660. [PubMed]
  • Evans AE. Staging and treatment of neuroblastoma. Cancer. 1980 Apr 15;45(7 Suppl):1799–1802. [PubMed]
  • Jereb B, Tournade MF, Lemerle J, Voûte PA, Delemarre JF, Ahstrom L, Flamant R, Gérard-Marchant R, Sandstedt B. Lymph node invasion and prognosis in nephroblastoma. Cancer. 1980 Apr 1;45(7):1632–1636. [PubMed]
  • Breslow NE, Palmer NF, Hill LR, Buring J, D'Angio GJ. Wilms' tumor: prognostic factors for patients without metastases at diagnosis: results of the National Wilms' Tumor Study. Cancer. 1978 Apr;41(4):1577–1589. [PubMed]
  • Castleberry RP, Crist WM, Cain WS, Holbrook T, Malluh A, Salter MM. Management of localized thoracic neuroblastoma. Med Pediatr Oncol. 1979;7(2):153–161. [PubMed]
  • Evans AE, Albo V, D'Angio GJ, Finklestein JZ, Leiken S, Santulli T, Weiner J, Hammond GD. Factors influencing survival of children with nonmetastatic neuroblastoma. Cancer. 1976 Aug;38(2):661–666. [PubMed]
  • Coldman AJ, Fryer CJ, Elwood JM, Sonley MJ. Neuroblastoma: influence of age at diagnosis, stage, tumor site, and sex on prognosis. Cancer. 1980 Oct 15;46(8):1896–1901. [PubMed]
  • Adam A, Hochholzer L. Ganglioneuroblastoma of the posterior mediastinum: a clinicopathologic review of 80 cases. Cancer. 1981 Jan 15;47(2):373–381. [PubMed]
  • Punt J, Pritchard J, Pincott JR, Till K. Neuroblastoma: a review of 21 cases presenting with spinal cord compression. Cancer. 1980 Jun 15;45(12):3095–3101. [PubMed]
  • Filler RM, Traggis DG, Jaffe N, Vawter GF. Favorable outlook for children with mediastinal neuroblastoma. J Pediatr Surg. 1972 Apr;7(2):136–143. [PubMed]
  • Finklestein JZ, Klemperer MR, Evans A, Bernstein I, Leikin S, McCreadie S, Grosfeld J, Hittle R, Weiner J, Sather H, et al. Multiagent chemotherapy for children with metastatic neuroblastoma: a report from Childrens Cancer Study Group. Med Pediatr Oncol. 1979;6(2):179–188. [PubMed]
  • Ninane J, Pritchard J, Malpas JS. Chemotherapy of advanced neuroblastoma: does adriamycin contribute? Arch Dis Child. 1981 Jul;56(7):544–548. [PMC free article] [PubMed]
  • Alexander J, Dainiak N, Berger HJ, Goldman L, Johnstone D, Reduto L, Duffy T, Schwartz P, Gottschalk A, Zaret BL. Serial assessment of doxorubicin cardiotoxicity with quantitative radionuclide angiocardiography. N Engl J Med. 1979 Feb 8;300(6):278–283. [PubMed]

Articles from Archives of Disease in Childhood are provided here courtesy of BMJ Publishing Group