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Arch Dis Child. 1981 May; 56(5): 397–399.
PMCID: PMC1627445

Delayed separation of the umbilical cord, severe widespread infections, and immunodeficiency.


Three of 4 children in a family died from infection before age one year. All 3 had delayed separation of the umbilical cord in the third week. One child was found to have defects both in specific antibody production and in neutrophil function; these were not improved by treatment with ascorbic acid or levamisole.

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Selected References

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  • Hayward AR, Harvey BA, Leonard J, Greenwood MC, Wood CB, Soothill JF. Delayed separation of the umbilical cord, widespread infections, and defective neutrophil mobility. Lancet. 1979 May 26;1(8126):1099–1101. [PubMed]
  • De Cree J, Emmery L, Timmermans J, Eeckels R, De Cock W, Verhaegen H. Defective neutrophil chemotaxis and raised serum ige levels in a child with recurrent bacterial infections and eczema. Influence of levamisole. Arch Dis Child. 1978 Feb;53(2):144–149. [PMC free article] [PubMed]
  • Blaese RM, Strober W, Brown RS, Waldmann TA. The Wiskott-Aldrich syndrome. A disorder with a possible defect in antigen processing or recognition. Lancet. 1968 May 18;1(7551):1056–1061. [PubMed]

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