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Arch Dis Child. 1981 November; 56(11): 878–880.
PMCID: PMC1627378

Percutaneous absorption of chlorhexidine in neonatal cord care.


The percutaneous absorption of chlorhexidine during its routine use in topical antiseptic preparations used in umbilical cord care was investigated by determining plasma chlorhexidine concentrations at ages 5 and 9 days. These showed that percutaneous absorption of chlorhexidine occurred in preterm neonates treated with a 1% solution of chlorhexidine in ethanol, but not in term infants similarly treated, or in preterm infants treated only with a dusting powder containing 1% chlorhexidine and 3% zinc oxide.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • BEEUWKES H. The use of chlorhexidine. Antonie Van Leeuwenhoek. 1958;24(1):49–62. [PubMed]
  • Lowbury EJ, Lilly HA. Use of 4 per cent chlorhexidine detergent solution (Hibiscrub) and other methods of skin disinfection. Br Med J. 1973 Mar 3;1(5852):510–515. [PMC free article] [PubMed]
  • Alder VG, Burman D, Simpson RA, Fysh J, Gillespie WA. Comparison of hexachlorophane and chlorhexidine powders in prevention of neonatal infection. Arch Dis Child. 1980 Apr;55(4):277–280. [PMC free article] [PubMed]
  • Tyrala EE, Hillman LS, Hillman RE, Dodson WE. Clinical pharmacology of hexachlorophene in newborn infants. J Pediatr. 1977 Sep;91(3):481–486. [PubMed]
  • Cowen J, Ellis SH, McAinsh J. Absorption of chlorhexidine from the intact skin of newborn infants. Arch Dis Child. 1979 May;54(5):379–383. [PMC free article] [PubMed]
  • Dubowitz LM, Dubowitz V, Goldberg C. Clinical assessment of gestational age in the newborn infant. J Pediatr. 1970 Jul;77(1):1–10. [PubMed]
  • Nachman RL, Esterly NB. Increased skin permeability in preterm infants. J Pediatr. 1971 Oct;79(4):628–632. [PubMed]

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