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Logo of archdischArchives of Disease in ChildhoodVisit this articleSubmit a manuscriptReceive email alertsContact usBMJ
Arch Dis Child. Jul 1981; 56(7): 563–565.
PMCID: PMC1627362
Purine nucleoside phosphorylase deficiency associated with a fatal lymphoproliferative disorder.
A R Watson, D I Evans, H B Marsden, V Miller, and P A Rogers
A 2 1/2-year-old boy presented with an illness resembling glandular fever. He was found to have T-cell deficiency with lack of red and white cell purine nucleoside phosphorylase enzyme activity. A spastic tetraparesis was noted. The patient subsequently died of a malignant lymphoma of the B-immunoblastic type.
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