PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of brmedjBMJ helping doctors make better decisionsSearchLatest content
 
Br Med J. Nov 25, 1978; 2(6150): 1457–1459.
PMCID: PMC1608703
Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia.
E K Perry, B E Tomlinson, G Blessed, K Bergmann, P H Gibson, and R H Perry
Abstract
Necropsy brain tissue from normal (control) patients and patients with depression and dementia was examined for activities of various cholinergic components, and these related to the degree of senile plaque formation and extent of intellectual impairment. Choline acetyltransferase and acetylcholinesterase activities decreased significantly as the mean plaque count rose, and in depressed and demented subjects the reduction in choline acetyltransferase activity correlated with the extent of intellectual impairment as measured by a memory information test; muscarinic cholinergic receptor binding activity remained unchanged with increasing senile plaque formation but butyrylcholinesterase activity increased. The results suggest a close relation between changes in the cholinergic system and Alzheimer's dementia, but the precise role of the system in this disease remains to be elucidated.
Full text
Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (608K), or click on a page image below to browse page by page.
Articles from British Medical Journal are provided here courtesy of
BMJ Publishing Group