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Br Med J. 1977 January 1; 1(6052): 18–20.
PMCID: PMC1603609

Preventing thromboembolism after myocardial infarction: effect of low-dose heparin or smoking.

Abstract

A trial of low-dose subcutaneous heparin to prevent thromboembolic complications after myocardial infarction was carried out in 78 patients. Of the 37 heparin-treated patients only two (5%) developed evidence of leg vein thrombosis, while 14 (34%) of the 41 controls did so, and five controls developed pulmonary emboli. Leg vein thrombosis developed in 12 (50%) of the 24 controls who did not smoke cigarettes but in only two (13%) of the 17 controls who were cigarette smokers. Non-smokers who have a myocardial infarction should be given low-dose heparin subcutaneously to prevent leg vein thrombosis and pulmonary embolism.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Maurer BJ, Wray R, Shillingford JP. Frequency of venous thrombosis after myocardial infarction. Lancet. 1971 Dec 25;2(7739):1385–1387. [PubMed]
  • Nicolaides AN, Kakkar VV, Renney JT, Kidner PH, Hutchison DC, Clarke MB. Myocardial infarction and deep-vein thrombosis. Br Med J. 1971 Feb 20;1(5746):432–434. [PMC free article] [PubMed]
  • Handley AJ, Emerson PA, Fleming PR. Heparin in the prevention of deep vein thrombosis after myocardial infarction. Br Med J. 1972 May 20;2(5811):436–438. [PMC free article] [PubMed]
  • Marks P, Emerson PA. Increased incidence of deep vein thrombosis after myocardial infarction in non-smokers. Br Med J. 1974 Jul 27;3(5925):232–234. [PMC free article] [PubMed]
  • Kakkar VV, Nicolaides AN, Renney JT, Friend JR, Clarke MB. 125-I-labelled fibrinogen test adapted for routine screening for deep-vein thrombosis. Lancet. 1970 Mar 14;1(7646):540–542. [PubMed]
  • Handley AJ. Low-dose heparin after myocardial infarction. Lancet. 1972 Sep 23;2(7778):623–624. [PubMed]
  • Steffensen KA. Coronary occlusion treated with small doses of heparin. Acta Med Scand. 1969 Dec;186(6):519–521. [PubMed]
  • Handley AJ, Teather D. Influence of smoking on deep vein thrombosis after myocardial infarction. Br Med J. 1974 Jul 27;3(5925):230–231. [PMC free article] [PubMed]
  • Doll R. Letter: Smoking and deep vein thrombosis. Br Med J. 1974 Aug 17;3(5928):466–466. [PMC free article] [PubMed]

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