Search tips
Search criteria 


Logo of brmedjLink to Publisher's site
Br Med J. 1977 January 1; 1(6052): 18–20.
PMCID: PMC1603609

Preventing thromboembolism after myocardial infarction: effect of low-dose heparin or smoking.


A trial of low-dose subcutaneous heparin to prevent thromboembolic complications after myocardial infarction was carried out in 78 patients. Of the 37 heparin-treated patients only two (5%) developed evidence of leg vein thrombosis, while 14 (34%) of the 41 controls did so, and five controls developed pulmonary emboli. Leg vein thrombosis developed in 12 (50%) of the 24 controls who did not smoke cigarettes but in only two (13%) of the 17 controls who were cigarette smokers. Non-smokers who have a myocardial infarction should be given low-dose heparin subcutaneously to prevent leg vein thrombosis and pulmonary embolism.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (627K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Maurer BJ, Wray R, Shillingford JP. Frequency of venous thrombosis after myocardial infarction. Lancet. 1971 Dec 25;2(7739):1385–1387. [PubMed]
  • Nicolaides AN, Kakkar VV, Renney JT, Kidner PH, Hutchison DC, Clarke MB. Myocardial infarction and deep-vein thrombosis. Br Med J. 1971 Feb 20;1(5746):432–434. [PMC free article] [PubMed]
  • Handley AJ, Emerson PA, Fleming PR. Heparin in the prevention of deep vein thrombosis after myocardial infarction. Br Med J. 1972 May 20;2(5811):436–438. [PMC free article] [PubMed]
  • Marks P, Emerson PA. Increased incidence of deep vein thrombosis after myocardial infarction in non-smokers. Br Med J. 1974 Jul 27;3(5925):232–234. [PMC free article] [PubMed]
  • Kakkar VV, Nicolaides AN, Renney JT, Friend JR, Clarke MB. 125-I-labelled fibrinogen test adapted for routine screening for deep-vein thrombosis. Lancet. 1970 Mar 14;1(7646):540–542. [PubMed]
  • Handley AJ. Low-dose heparin after myocardial infarction. Lancet. 1972 Sep 23;2(7778):623–624. [PubMed]
  • Steffensen KA. Coronary occlusion treated with small doses of heparin. Acta Med Scand. 1969 Dec;186(6):519–521. [PubMed]
  • Handley AJ, Teather D. Influence of smoking on deep vein thrombosis after myocardial infarction. Br Med J. 1974 Jul 27;3(5925):230–231. [PMC free article] [PubMed]
  • Doll R. Letter: Smoking and deep vein thrombosis. Br Med J. 1974 Aug 17;3(5928):466–466. [PMC free article] [PubMed]

Articles from British Medical Journal are provided here courtesy of BMJ Publishing Group