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Br Med J. 1980 June 7; 280(6228): 1351–1352.
PMCID: PMC1601833

The salutary effect of milk on amoebiasis and its reversal by iron.


Observations among milk-drinking African nomads showed an unusual freedom from infection with Entamoeba histolytica compared with similar nomads taking a mixed diet. A controlled study among Maasai pastoralists showed that the administration of iron to correct their dietary iron deficiency sharply increased their susceptibility to amoebiasis. Examination of the milk of their Zebu cattle showed that it not only had a concentration of iron below the minimum necessary for the growth of E histolytica but also contained partly saturated lactoferrin and transferrin, which may actively compete with the parasite in the colon for ambient iron. These observations suggest the possibility of a long-standing ecological compromise between nomads, their milk diet, and E histolytica.

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Selected References

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  • MAEGRAITH BG, DEEGAN T, JONES ES. Suppression of malaria (P. berghei) by milk. Br Med J. 1952 Dec 27;2(4799):1382–1384. [PMC free article] [PubMed]
  • BRAY RS, GARNHAM PCC. Effect of milk diet on P. cynomolgi infections in monkeys. Br Med J. 1953 May 30;1(4821):1200–1201. [PMC free article] [PubMed]
  • HAWKING F. Milk diet, p-aminobenzoic acid, and malaria (P. berghei); preliminary communication. Br Med J. 1953 May 30;1(4821):1201–1202. [PMC free article] [PubMed]
  • Murray MJ, Murray AB, Murray MB, Murray CJ. The adverse effect of iron repletion on the course of certain infections. Br Med J. 1978 Oct 21;2(6145):1113–1115. [PMC free article] [PubMed]
  • Murray MJ, Murray AB, Murray CJ. An ecological interdependence of diet and disease? A study of infection in one tribe consuming two different diets. Am J Clin Nutr. 1980 Mar;33(3):697–701. [PubMed]
  • Murray MJ, Murray AB, Murray NJ, Murray MB. The effect of iron status of Nigerien mothers on that of their infants at birth and 6 months, and on the concentration of Fe in breast milk. Br J Nutr. 1978 May;39(3):627–630. [PubMed]
  • Herbert V, Gottlieb CW, Lau KS, Fisher M, Gevirtz NR, Wasserman LR. Coated charcoal assay of unsaturated iron-binding capacity. J Lab Clin Med. 1966 May;67(5):855–862. [PubMed]
  • Masson PL, Heremans JF. Lactoferrin in milk from different species. Comp Biochem Physiol B. 1971 May 15;39(1):119–129. [PubMed]
  • Masson PL, Heremans JF. Metal-combining properties of human lactoferrin (red milk protein). 1. The involvement of bicarbonate in the reaction. Eur J Biochem. 1968 Dec 5;6(4):579–584. [PubMed]
  • Latour NG, Reeves RE. An iron-requirement for growth of Entamoeba histolytica in culture, and the antiamebal activity of 7-iodo-8-hydroxy-quinoline-5-sulfonic acid. Exp Parasitol. 1965 Oct;17(2):203–209. [PubMed]
  • Weinberg ED. Iron and susceptibility to infectious disease. Science. 1974 May 31;184(4140):952–956. [PubMed]
  • Brock JH, Arzabe F, Lampreave F, Piñeiro A. The effect of trypsin on bovine transferrin and lactoferrin. Biochim Biophys Acta. 1976 Sep 28;446(1):214–225. [PubMed]
  • Diamond LS, Harlow DR, Phillips BP, Keister DB. Entamoeba histolytica: iron and nutritional immunity. Arch Invest Med (Mex) 1978;9 (Suppl 1):329–338. [PubMed]

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