Search tips
Search criteria 


Logo of brmedjLink to Publisher's site
Br Med J. 1973 November 24; 4(5890): 464–466.
PMCID: PMC1587569

Local Effect of Intranasal Beclomethasone Dipropionate Aerosol in Hay Fever


The effect of a daily dose of 400 μg beclomethasone dipropionate aerosol intranasally has been investigated in a double-blind cross-over trial in 29 patients with hay fever. The effect on the nasal symptoms was so pronounced in 25 patients that further symptomatic treatment was unnecessary. Beclomethasone dipropionate aerosol had, on the other hand, no direct effect on itching in the eyes, which is in accordance with the fact that biochemical investigations did not show any sign of suppression of the adrenal function. It is concluded that beclomethasone dipropionate aerosol intranasally is an effective and apparently harmless way of controlling the nasal symptoms in hay fever.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (669K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Brown HM, Storey G, George WH. Beclomethasone dipropionate: a new steroid aerosol for the treatment of allergic asthma. Br Med J. 1972 Mar 4;1(5800):585–590. [PMC free article] [PubMed]
  • FEW JD. A method for the analysis of urinary 17-hydroxycorticosteroids. J Endocrinol. 1961 Mar;22:31–46. [PubMed]
  • FOULDS WS, GREAVES DP, HERX-HEIMER H, KINGDOM LG. Hydrocortisone in treatment of allergic conjunctivitis, allergic rhinitis, and bronchial asthma. Lancet. 1955 Jan 29;268(6857):234–235. [PubMed]
  • Gaddie J, Reid IW, Skinner C, Petrie GR, Sinclair DJ, Palmer KN. Aerosol beclomethasone dipropionate in chronic bronchial asthma. Lancet. 1973 Mar 31;1(7805):691–693. [PubMed]
  • Ganderton MA, Brostoff J, Frankland AW. Comparison of preseasonal and coseasonal Allpyral with Depo-Medrone in summer hay-fever. Br Med J. 1969 Feb 8;1(5640):357–358. [PMC free article] [PubMed]
  • GODFREY MP, MAUNSELL K, PEARSON RSB. Prednisolone snuff in hayfever; a controlled trial. Lancet. 1957 Apr 13;272(6972):767–769. [PubMed]
  • Lal S, Harris DM, Bhalla KK, Singhal SN, Butler AG. Comparison of beclomethasone dipropionate aerosol and prednisolone in reversible airways obstruction. Br Med J. 1972 Aug 5;3(5822):314–317. [PMC free article] [PubMed]
  • Maberly DJ, Gibson GJ, Butler AG. Recovery of adrenal function after substitution of beclomethasone dipropionate for oral corticosteroids. Br Med J. 1973 Mar 31;1(5856):778–779. [PMC free article] [PubMed]
  • Norman PS, Winkenwerder WL, Agbayani BF, Migeon CJ. Adrenal function during the use of dexamethasone aerosols in the treatment of ragweed hay fever. J Allergy. 1967 Jul;40(1):57–61. [PubMed]
  • UHDE H. Aerosoltherapie mit Prednisolonlösung; eigene Erfahrungen. Munch Med Wochenschr. 1957 Jun 14;99(24):891–893. [PubMed]

Articles from British Medical Journal are provided here courtesy of BMJ Publishing Group