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Environ Health Perspect. 1990 November; 89: 75–78.
PMCID: PMC1567783
Research Article

Environmental lead toxicity: nutrition as a component of intervention.


The influence of nutritional status on susceptibility to the toxicity of lead is discussed. Emphasis is given to dietary factors of substantial clinical importance. Subtle changes in susceptibility are difficult to evaluate under conditions of overwhelming lead exposure. It is clear that subtle effects of lead exposure on neurobehavioral and cognitive development are a major concern. The role of nutrition is considered to be an adjunct to reduction of environmental lead exposure, which is the primary means of reducing adverse health effects of lead. Nutrition should be evaluated as a component of strategies to address this broad societal issue.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Bellinger DC, Needleman HL, Leviton A, Waternaux C, Rabinowitz MB, Nichols ML. Early sensory-motor development and prenatal exposure to lead. Neurobehav Toxicol Teratol. 1984 Sep-Oct;6(5):387–402. [PubMed]
  • Dietrich KN, Krafft KM, Bornschein RL, Hammond PB, Berger O, Succop PA, Bier M. Low-level fetal lead exposure effect on neurobehavioral development in early infancy. Pediatrics. 1987 Nov;80(5):721–730. [PubMed]
  • McMichael AJ, Baghurst PA, Wigg NR, Vimpani GV, Robertson EF, Roberts RJ. Port Pirie Cohort Study: environmental exposure to lead and children's abilities at the age of four years. N Engl J Med. 1988 Aug 25;319(8):468–475. [PubMed]
  • Mahaffey KR, Annest JL. Association of erythrocyte protoporphyrin with blood lead level and iron status in the second National Health and Nutrition Examination Survey, 1976-1980. Environ Res. 1986 Oct;41(1):327–338. [PubMed]
  • Rabinowitz MB, Kopple JD, Wetherill GW. Effect of food intake and fasting on gastrointestinal lead absorption in humans. Am J Clin Nutr. 1980 Aug;33(8):1784–1788. [PubMed]
  • Blake KC, Mann M. Effect of calcium and phosphorus on the gastrointestinal absorption of 203Pb in man. Environ Res. 1983 Feb;30(1):188–194. [PubMed]
  • Watson WS, Hume R, Moore MR. Oral absorption of lead and iron. Lancet. 1980 Aug 2;2(8188):236–237. [PubMed]
  • Watson WS, Morrison J, Bethel MI, Baldwin NM, Lyon DT, Dobson H, Moore MR, Hume R. Food iron and lead absorption in humans. Am J Clin Nutr. 1986 Aug;44(2):248–256. [PubMed]
  • Six KM, Goyer RA. The influence of iron deficiency on tissue content and toxicity of ingested lead in the rat. J Lab Clin Med. 1972 Jan;79(1):128–136. [PubMed]
  • Ragan HA. Effects of iron deficiency on the absorption and distribution of lead and cadmium in rats. J Lab Clin Med. 1977 Oct;90(4):700–706. [PubMed]
  • Hamilton DL. Interrelationships of lead and iron retention in iron-deficient mice. Toxicol Appl Pharmacol. 1978 Dec;46(3):651–661. [PubMed]
  • Sullivan MF, Ruemmler PS. Effect of excess Fe on Cd or Pb absorption by rats. J Toxicol Environ Health. 1987;22(2):131–139. [PubMed]
  • Six KM, Goyer RA. Experimental enhancement of lead toxicity by low dietary calcium. J Lab Clin Med. 1970 Dec;76(6):933–942. [PubMed]
  • Mahaffey KR, Goyer R, Haseman JK. Dose-response to lead ingestion in rats fed low dietary calcium. J Lab Clin Med. 1973 Jul;82(1):92–100. [PubMed]
  • Keller CA, Doherty RA. Bone lead mobilization in lactating mice and lead transfer to suckling offspring. Toxicol Appl Pharmacol. 1980 Sep 15;55(2):220–228. [PubMed]
  • Thompson GN, Robertson EF, Fitzgerald S. Lead mobilization during pregnancy. Med J Aust. 1985 Aug 5;143(3):131–131. [PubMed]
  • Silbergeld EK, Schwartz J, Mahaffey K. Lead and osteoporosis: mobilization of lead from bone in postmenopausal women. Environ Res. 1988 Oct;47(1):79–94. [PubMed]
  • Pollitt E, Leibel RL. Iron deficiency and behavior. J Pediatr. 1976 Mar;88(3):372–381. [PubMed]
  • Oski FA, Honig AS. The effects of therapy on the developmental scores of iron-deficient infants. J Pediatr. 1978 Jan;92(1):21–25. [PubMed]
  • Lozoff B, Brittenham GM, Viteri FE, Wolf AW, Urrutia JJ. Developmental deficits in iron-deficient infants: effects of age and severity of iron lack. J Pediatr. 1982 Dec;101(6):948–952. [PubMed]
  • Oski FA, Honig AS, Helu B, Howanitz P. Effect of iron therapy on behavior performance in nonanemic, iron-deficient infants. Pediatrics. 1983 Jun;71(6):877–880. [PubMed]

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