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Environ Health Perspect. Jun 1990; 86: 313–321.
PMCID: PMC1567743
Research Article
An overview of prechronic and chronic toxicity/carcinogenicity experimental study designs and criteria used by the National Toxicology Program.
R S Chhabra, J E Huff, B S Schwetz, and J Selkirk
National Institute of Environmental Health Sciences, National Toxicology Program, Research Triangle Park, NC 27709.
Abstract
Since the establishment of the National Toxicology Program (NTP), there have been gradual changes in strategies to evaluate the overall toxicity of chemicals as well as their carcinogenic potential. The spectrum of toxicologic information sought on selected chemicals has been broadened by the multidisciplinary approach to evaluating chemicals. This paper describes the scientific rationale and experimental processes used by NTP in designing studies. Also, an outline of current NTP protocols are given for prechronic and chronic toxicity/carcinogenicity studies.
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