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Gut. 1969 November; 10(11): 871–881.
PMCID: PMC1553062

Solitary ulcer of the rectum


Solitary ulcer of the rectum is usually a disease of young adults of either sex which has a characteristic appearance on sigmoidoscopy. Distinctive changes may also be seen in biopsies taken from mucosa adjacent to the ulcer.

The name `solitary ulcer' is misleading because more than one ulcer may be present. Moreover, there is a preulcerative phase which is clinically and histologically recognizable.

The condition is essentially benign and may persist for many years unchanged. It has not responded satisfactorily to medical or surgical methods of treatment.

The cause of solitary ulcer is unknown. Different views on the pathogenesis are discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Allen MS., Jr Hamartomatous inverted polyps of the rectum. Cancer. 1966 Feb;19(2):257–265. [PubMed]
  • Epstein SE, Ascari WQ, Ablow RC, Seaman WB, Lattes R. Colitis cystica profunda. Am J Clin Pathol. 1966 Feb;45(2):186–201. [PubMed]
  • Haskell B, Rovner H. Solitary ulcer of the rectum. Dis Colon Rectum. 1965 Sep-Oct;8(5):333–336. [PubMed]

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