PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of archdischArchives of Disease in ChildhoodVisit this articleSubmit a manuscriptReceive email alertsContact usBMJ
 
Arch Dis Child. 1976 February; 51(2): 91–99.
PMCID: PMC1545884

Defective opsonization. A common immunity deficiency.

Abstract

Serum opsonization of yeasts for phagocytosis by normal polymorphonuclear leucocytes was defective in 11 of 43 children with unexplained frequent infections. The children had a range of infections, largely bacterial, and only 3 had diarrhoea and rash in infancy. A similar defect in at least 6 of the 9 mothers of these children (of either sex), with normal function in the fathers, suggests that the defect was primary and was transmitted by an unusual form of dominant inheritance. Four of 72 healthy adults and 1 of 11 children with unrelated disease showed similar defective function, but the incidence of the defect in the patients with frequent infection was significantly greater than this. The defective function can be corrected, in vitro and in vivo, by normal plasma at concentrations too low to be effective alone. This suggests that there is a defective factor rather than an inhibitor, and that different factors are limiting in normal and in defective plasma. Sera from affected members of the same family do not correct each other, but defective sera from different families usually do.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.1M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Feldmann M, Pepys MB. Role of C3 in in vitro lymphocyte cooperation. Nature. 1974 May 10;249(453):159–161. [PubMed]
  • Gleich GJ, Averbeck AK, Swedlund HA. Measurement of IgE in normal and allergic serum by radioimmunoassay. J Lab Clin Med. 1971 Apr;77(4):690–698. [PubMed]
  • Jacobs JC, Miller ME. Fatal familial Leiner's disease: a deficiency of the opsonic activity of serum complement. Pediatrics. 1972 Feb;49(2):225–232. [PubMed]
  • Mancini G, Carbonara AO, Heremans JF. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965 Sep;2(3):235–254. [PubMed]
  • Miller ME, Nilsson UR. A familial deficiency of the phagocytosis-enhancing activity of serum related to a dysfunction of the fifth component of complement (C5). N Engl J Med. 1970 Feb 12;282(7):354–358. [PubMed]
  • Scott H, Moynahan EJ, Risdon RA, Harvey BA, Soothill JF. Familial opsonization defect associated with fatal infantile dermatitis, infections, and histiocytosis. Arch Dis Child. 1975 Apr;50(4):311–317. [PMC free article] [PubMed]
  • SEGRE D, MYERS WL. ANTIBODY PRODUCTION IN BABY PIGS. Am J Vet Res. 1964 Mar;25:413–419. [PubMed]
  • Taylor B, Norman AP, Orgel HA, Stokes CR, Turner MW, Soothill JF. Transient IgA deficiency and pathogenesis of infantile atopy. Lancet. 1973 Jul 21;2(7821):111–113. [PubMed]
  • Till MM, Jones LH, Pentycross CR, Hardisty RM, Lawler SD, Harvey BA, Soothill JF. Leukaemia in children and their grandparents: studies of immune function in six families. Br J Haematol. 1975 Apr;29(4):575–586. [PubMed]

Articles from Archives of Disease in Childhood are provided here courtesy of BMJ Group