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Arch Dis Child. 1978 July; 53(7): 594–596.
PMCID: PMC1545005

Propranolol as an antihypertensive agent in children.


The antihypertensive effect of oral propranolol was studied in 9 children with hypertension. After treatment with propranolol, systolic blood pressure fell by an average of 26 mmHg (P less than 0.01). Diastolic pressure decreased by 20 mmHg on average (P less than 0.01). The mean propranolol dose was 2.5 mg/kg per day. Side effects included bradycardia and anorexia. There was no correlation between pretreatment plasma renin activity and fall in blood pressure. Propranolol is an effective and well tolerated antihypertensive agent in children.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Holland OB, Kaplan NM. Propranolol in the treatment of hypertension. N Engl J Med. 1976 Apr 22;294(17):930–936. [PubMed]
  • Laragh JH, Baer L, Brunner HR, Buhler FR, Sealey JE, Vaughan ED., Jr Renin, angiotensin and aldosterone system in pathogenesis and management of hypertensive vascular disease. Am J Med. 1972 May;52(5):633–652. [PubMed]
  • Nies AS, Shand DG. Clinical pharmacology of propranolol. Circulation. 1975 Jul;52(1):6–15. [PubMed]
  • Prichard BN, Ross EJ. Use of propranolol in conjunction with alpha receptor blocking drugs in pheochromocytoma. Am J Cardiol. 1966 Sep;18(3):394–398. [PubMed]
  • Tarazi RC, Dustan HP. Beta adrenergic blockade in hypertension. Practical and theoretical implications of long-term hemodynamic variations. Am J Cardiol. 1972 May;29(5):633–640. [PubMed]

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