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Logo of procrsmedFormerly medchtJournal of the Royal Society of MedicineProceedings of the Royal Society of Medicine
 
Proc R Soc Med. 1977; 70(Suppl 3): 61–64.
PMCID: PMC1543609

An outline of D-penicillamine metabolism.

Abstract

In a study using 14C-D-penicillamine in a normal subject only 50% of the D-penicillamine was absorbed from the gut. The major urinary metabolites are cysteine-penicillamine and penicillamine disulphide. S-methyl-D-penicillamine is the only biochemically transformed metabolite so far identified.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • CRAWHALL JC, SCOWEN EF, WATTS RW. Effect of penicillamine on cystinuria. Br Med J. 1963 Mar 2;1(5330):588–590. [PMC free article] [PubMed]
  • CRAWHALL JC, THOMPSON CJ. CYSTINURIA: EFFECT OF D-PENICILLAMINE ON PLASMA AND URINARY CYSTINE CONCENTRATIONS. Science. 1965 Mar 19;147(3664):1459–1460. [PubMed]
  • Gibbs K, Walshe JM. Studies with 35S-labelled DL-penicillamine in patients with Wilson's disease. Q J Med. 1971 Apr;40(158):275–287. [PubMed]
  • Perrett D, Sneddon W, Stephens AD. Studies on D-penicillamine metabolism in cystinuria and rheumatoid arthritis: isolation of S-methyl-D-penicillamine. Biochem Pharmacol. 1976 Feb 1;25(3):259–264. [PubMed]
  • Planas-Bohne F. Pharmakokinetische Untersuchungen an 14 C-markiertem Penicillamin. Arzneimittelforschung. 1972 Sep;22(9):1426–1433. [PubMed]
  • Ruiz-Torres A. Zur Pharmakokinetik und zum Stoffwechsel von D- und L-Penicillamin. 1. Blutspiggel, Transport und Eiweissbindung. Arzneimittelforschung. 1974 Jun;24(6):914–917. [PubMed]
  • Ruiz-Torres A, Kürten I. Zur Pharmakokinetik und zum Stoffwechsel von D- und L-Penicillamin 3. Mitteilung: Resorption, Ausscheidung und Metabolisierung. Arzneimittelforschung. 1974 Sep;24(9):1258–1261. [PubMed]
  • Wass M, Evered DF. Transport of penicillamine across mucosa of the rat small intestine in vitro. Biochem Pharmacol. 1970 Apr;19(4):1287–1295. [PubMed]

Articles from Proceedings of the Royal Society of Medicine are provided here courtesy of Royal Society of Medicine Press